Diprivanpropofol
According to the FDA label: Propofol injectable emulsion is an intravenous general anesthetic and sedation drug indicated for: Induction of General Anesthesia for Patients Greater than or Equal to 3 Years of Age Maintenance of General Anesthesia for Patients Greater than or Equal to 2 Months of Age Initiation and Maintenance of Monitored Anesthesia Care (MAC) Sedation in Adult Patients Sedation for Adult Patients in Combination with Regional Anesthesia Intensive Care Unit (ICU) Sedation of Intubated, Mechanically…
35,666 adverse event reports submitted to the FDA (1998–2026)
Top Reported Adverse Events
The most frequently reported events in association with Diprivan in the FAERS database. These are events reported by patients taking this medication, not necessarily caused by it. A single report may include multiple events.
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Hypotension 2,865 reports
Drug Ineffective 2,734 reports
A report that the medication did not work as expected for the person taking it. This is a reporting category, not a sign the drug is defective. It simply means someone felt it was not helping their condition.
Full definition in the glossary →- Anaphylactic Shock 2,033 reports
Cardiac Arrest 1,800 reports
A sudden stop in the heart's pumping, a medical emergency.
Full definition in the glossary →Anaphylactic Reaction 1,669 reports
A severe, rapid allergic reaction that can be life-threatening and needs emergency care.
Full definition in the glossary →Off Label Use 1,655 reports
Using a medication for a condition or in a way that the FDA has not officially approved. This is common and often legal, and a report of it does not mean something went wrong. Doctors sometimes prescribe drugs off label based on their judgment.
Full definition in the glossary →Drug Interaction 1,540 reports
A report that two or more medications may have affected each other when taken together.
Full definition in the glossary →Tachycardia 1,189 reports
A faster than normal heart rate.
Full definition in the glossary → See all drugs reporting this event →Bradycardia 1,176 reports
A slower than normal heart rate.
Full definition in the glossary →Pyrexia 1,001 reports
The medical term for fever, meaning a raised body temperature.
Full definition in the glossary → See all drugs reporting this event →Acute Kidney Injury 984 reports
A sudden drop in how well the kidneys are working. It is often temporary and can have many causes.
Full definition in the glossary →Rhabdomyolysis 905 reports
A serious condition where muscle tissue breaks down and releases substances that can harm the kidneys.
Full definition in the glossary →Renal Failure 804 reports
A serious decline in kidney function, where the kidneys can no longer filter waste properly.
Full definition in the glossary →- Bronchospasm 803 reports
Oxygen Saturation Decreased 799 reports
A reading showing a lower than normal level of oxygen in the blood.
Full definition in the glossary →
Ranked by frequency of reports, not severity. The most-reported event is not necessarily the most dangerous or the most common in patients taking this drug.
Who Is Reporting
Demographics of patients in FAERS reports that included this information. Not all reports include patient demographics.
By Sex
View reporter sex data as a table
| Sex | Reports |
|---|---|
| Female | 16,085 |
| Male | 15,589 |
| Unknown | 231 |
By Age Group
View age group data as a table
| Age group | Reports |
|---|---|
| 0-17 | 3,136 |
| 18-34 | 5,308 |
| 35-49 | 5,407 |
| 50-64 | 7,142 |
| 65-74 | 4,679 |
| 75+ | 2,956 |
This shows who filed reports, reflecting who takes this drug and who tends to report, not who is at greatest risk.
Reported Outcomes
Outcomes recorded in FAERS reports that included Diprivan. A single report may involve multiple reactions, each with a different outcome. These categories are defined by FDA reporting guidelines, not by PillSignal.
View outcome data as a table
| Outcome | Reports |
|---|---|
| Other Serious | 20,546 |
| Hospitalization | 15,193 |
| Life-Threatening | 8,946 |
| Death | 4,869 |
| Non-Serious | 2,230 |
| Disability | 925 |
Serious outcomes are far more likely to be reported than mild ones, so this overstates how often outcomes are serious. A recorded death does not mean the drug caused it.
Report Volume Over Time
Number of FAERS reports received per quarter for Diprivan. Changes in volume may reflect shifts in prescribing rates, media attention, or reporting behavior, not changes in the medication's safety profile.
View report trend as a table
| Year | Reports |
|---|---|
| 1998 | 4 |
| 2000 | 2 |
| 2001 | 4 |
| 2002 | 1 |
| 2003 | 2 |
| 2004 | 582 |
| 2005 | 674 |
| 2006 | 630 |
| 2007 | 791 |
| 2008 | 798 |
| 2009 | 1,132 |
| 2010 | 976 |
| 2011 | 1,397 |
| 2012 | 1,187 |
| 2013 | 1,248 |
| 2014 | 1,148 |
| 2015 | 1,307 |
| 2016 | 1,622 |
| 2017 | 1,594 |
| 2018 | 2,060 |
| 2019 | 2,180 |
| 2020 | 2,738 |
| 2021 | 2,486 |
| 2022 | 2,361 |
| 2023 | 2,778 |
| 2024 | 2,476 |
| 2025 | 2,891 |
| 2026 (partial) | 597 |
The steep increase around 2004 reflects the FDA's move to electronic submission, not a change in this drug's safety. Trends track reporting volume, not risk.
Medications commonly reported with Diprivan
In FDA adverse event reports that mention Diprivan, these medications appeared most often in the same report.
- Fentanyl (11,115 reports)
- Midazolam (8,764 reports)
- Rocuronium (6,537 reports)
- Lidocaine (4,539 reports)
- Sevoflurane (4,487 reports)
This reflects co-occurrence in submitted reports, not evidence of drug interaction or combined risk. People often report several medications taken for the same condition or for unrelated reasons. Talk to a doctor or pharmacist about your specific medications.
Related Drugs
Other medications with similar adverse event profiles in FDA FAERS reports.
Data Source
This data is sourced from the FDA's Adverse Event Monitoring System (AEMS), formerly FAERS, via the OpenFDA API. PillSignal is not affiliated with the FDA.
View this data on the FDA website →Data last updated: June 2026