Panoxyladapalene
According to the FDA label: Use For the treatment of acne
8,076 adverse event reports submitted to the FDA (2004–2026)
Top Reported Adverse Events
The most frequently reported events in association with Panoxyl in the FAERS database. These are events reported by patients taking this medication, not necessarily caused by it. A single report may include multiple events.
Show these terms with plain-language definitions
Tap any term below for a plain-language definition.
Drug Ineffective 2,691 reports
A report that the medication did not work as expected for the person taking it. This is a reporting category, not a sign the drug is defective. It simply means someone felt it was not helping their condition.
Full definition in the glossary →Dry Skin 862 reports
Skin that lacks moisture, which can feel rough, tight, or flaky.
Full definition in the glossary → See all drugs reporting this event →Condition Aggravated 620 reports
A report that the person's existing health condition got worse. This describes a worsening of something the person already had, not necessarily a new problem caused by the drug.
Full definition in the glossary →Rash 559 reports
An area of irritated, red, or bumpy skin.
Full definition in the glossary → See all drugs reporting this event →Acne 543 reports
A skin condition causing pimples, usually on the face, chest, or back.
Full definition in the glossary → See all drugs reporting this event →- Skin Burning Sensation 519 reports
Erythema 504 reports
Redness of the skin.
Full definition in the glossary →- Skin Irritation 500 reports
Pruritus 398 reports
Hypersensitivity 344 reports
An exaggerated reaction by the immune system, similar to an allergic reaction.
Full definition in the glossary →Skin Exfoliation 316 reports
Peeling or shedding of the outer layer of skin.
Full definition in the glossary →Pain 287 reports
A general report of physical discomfort, used when no more specific location is given.
Full definition in the glossary →Off Label Use 253 reports
Using a medication for a condition or in a way that the FDA has not officially approved. This is common and often legal, and a report of it does not mean something went wrong. Doctors sometimes prescribe drugs off label based on their judgment.
Full definition in the glossary →Vomiting 253 reports
Throwing up the contents of the stomach.
Full definition in the glossary → See all drugs reporting this event →Nausea 252 reports
The feeling of sickness in your stomach that often comes before vomiting.
Full definition in the glossary → See all drugs reporting this event →
Ranked by frequency of reports, not severity. The most-reported event is not necessarily the most dangerous or the most common in patients taking this drug.
Who Is Reporting
Demographics of patients in FAERS reports that included this information. Not all reports include patient demographics.
By Sex
View reporter sex data as a table
| Sex | Reports |
|---|---|
| Female | 3,488 |
| Male | 1,940 |
| Unknown | 19 |
By Age Group
View age group data as a table
| Age group | Reports |
|---|---|
| 0-17 | 614 |
| 18-34 | 726 |
| 35-49 | 569 |
| 50-64 | 537 |
| 65-74 | 330 |
| 75+ | 195 |
This shows who filed reports, reflecting who takes this drug and who tends to report, not who is at greatest risk.
Reported Outcomes
Outcomes recorded in FAERS reports that included Panoxyl. A single report may involve multiple reactions, each with a different outcome. These categories are defined by FDA reporting guidelines, not by PillSignal.
View outcome data as a table
| Outcome | Reports |
|---|---|
| Non-Serious | 5,393 |
| Other Serious | 1,957 |
| Hospitalization | 966 |
| Death | 637 |
| Life-Threatening | 229 |
| Disability | 173 |
Serious outcomes are far more likely to be reported than mild ones, so this overstates how often outcomes are serious. A recorded death does not mean the drug caused it.
Report Volume Over Time
Number of FAERS reports received per quarter for Panoxyl. Changes in volume may reflect shifts in prescribing rates, media attention, or reporting behavior, not changes in the medication's safety profile.
View report trend as a table
| Year | Reports |
|---|---|
| 2004 | 18 |
| 2005 | 17 |
| 2006 | 32 |
| 2007 | 22 |
| 2008 | 31 |
| 2009 | 33 |
| 2010 | 52 |
| 2011 | 62 |
| 2012 | 63 |
| 2013 | 84 |
| 2014 | 102 |
| 2015 | 174 |
| 2016 | 158 |
| 2017 | 183 |
| 2018 | 254 |
| 2019 | 282 |
| 2020 | 316 |
| 2021 | 265 |
| 2022 | 288 |
| 2023 | 458 |
| 2024 | 1,181 |
| 2025 | 1,216 |
| 2026 (partial) | 2,785 |
The steep increase around 2004 reflects the FDA's move to electronic submission, not a change in this drug's safety. Trends track reporting volume, not risk.
Medications commonly reported with Panoxyl
In FDA adverse event reports that mention Panoxyl, these medications appeared most often in the same report.
- Salicylic Acid (1,862 reports)
- Astringent (1,792 reports)
- Bosye Benefiting Hair Lotion (1,792 reports)
- Callus Removers (1,792 reports)
- Clear Medicated Corn Removers (1,792 reports)
This reflects co-occurrence in submitted reports, not evidence of drug interaction or combined risk. People often report several medications taken for the same condition or for unrelated reasons. Talk to a doctor or pharmacist about your specific medications.
Related Drugs
Other medications with similar adverse event profiles in FDA FAERS reports.
Data Source
This data is sourced from the FDA's Adverse Event Monitoring System (AEMS), formerly FAERS, via the OpenFDA API. PillSignal is not affiliated with the FDA.
View this data on the FDA website →Data last updated: June 2026