These are medications for which depression appears among the most-reported events in FDA adverse event reports. A report does not mean the drug caused the event. Report counts largely reflect how widely a drug is used and how often events are reported; they cannot be used to compare or rank drugs by risk. This list shows drugs where this event is among their top reported reactions, not every drug ever associated with it. This information is not medical advice. Do not stop or change a medication based on this data; discuss any concerns with your healthcare provider. Data from the FDA Adverse Event Monitoring System (AEMS), formerly FAERS, via OpenFDA.

A persistent low mood, loss of interest, or feelings of sadness. If you are struggling, the 988 Suicide and Crisis Lifeline (call or text 988 in the US) is available 24 hours a day. Full definition in the glossary →

437 drugs meet the threshold; showing the 100 most-reported.

Medications with FDA adverse event reports of depression, by report count
DrugReports of this event% of drug's total reports
Neurontin10,0102.8%
Vitamin D9,4852.5%
Chantix8,32410.9%
Klonopin8,1895.2%
OxyContin7,7233.7%
Xanax XR7,2713.6%
Gralise7,2412.5%
Xanax7,2243.6%
Gabapentin7,1582.5%
Gabarone7,1582.5%
Cymbalta6,8645.0%
Lyrica6,6622.5%
Seroquel XR6,3683.9%
Prinivil6,1572.0%
Zestril6,1572.0%
Omeprazole5,9891.8%
Ativan5,9393.4%
Seroquel5,8983.9%
Synthroid5,8802.1%
Zoloft5,8295.6%
Lisinopril5,8262.0%
Qbrelis5,8262.0%
Wellbutrin XL5,7196.5%
Lexapro5,6724.6%
Advil5,6602.4%
Clonazepam5,5514.8%
Otezla5,4883.8%
Motrin Infants5,4782.6%
Wellbutrin SR5,2736.8%
Lamictal XR5,0633.9%
Lamictal ODT5,0463.9%
Lamictal5,0423.9%
Advil Liqui-gels4,9242.5%
Motrin Ib4,9062.5%
Advil Migraine4,8732.5%
Ibuprofen4,8692.5%
Caldolor4,8672.5%
Motrin Ib Migraine4,8672.5%
Oxycodone Hydrochloride4,7882.6%
Fosamax4,6205.6%
Mirena4,5453.3%
Effexor XR4,4345.9%
Albuterol4,4182.3%
Celebrex4,3703.4%
Celexa4,3413.9%
Zocor4,1901.7%
Accutane4,18814.6%
Lipitor4,0801.7%
Quetiapine Fumarate4,0263.9%
Singulair3,9403.3%
Valium3,8823.3%
Abilify3,8773.4%
Nexium3,7752.1%
Loreev XR3,7682.9%
Lorazepam3,7672.9%
Naproxen3,6774.2%
Prozac3,6696.0%
Prevacid3,6012.1%
Avonex3,5702.5%
Topamax3,5664.0%
Citalopram3,5473.4%
Propecia3,4676.7%
Ambien CR3,4154.0%
Paxil CR3,3635.8%
Sertraline3,3593.3%
Ambien3,2834.0%
Protonix Delayed-release3,2612.3%
Remeron3,2463.6%
ProAir HFA3,1922.7%
Tysabri3,1851.8%
Crestor3,1761.6%
Paxil3,1195.8%
Ms Contin3,0432.5%
Xyrem3,0264.9%
Alprazolam Extended Release2,9942.7%
Alprazolam2,9932.7%
Alprazolam XR2,9932.7%
Naprosyn2,9423.8%
Ag-x2,9262.0%
Hydrochlorothiazide2,8662.0%
Inzirqo2,8662.0%
Microzide2,8662.0%
Cipro2,7362.9%
Dilaudid2,7333.0%
Hydrocodone Bitartrate And Acetaminophen2,7264.9%
Fluoxetine2,7153.5%
Tenormin2,6962.0%
Effexor2,6273.8%
Venlafaxine2,6273.8%
Zyprexa Zydis2,6182.5%
Prilosec2,6112.5%
Altace2,6052.1%
Ramipril2,6052.1%
Zyprexa2,5992.5%
Zyprexa Intramuscular2,5992.5%
Virazole2,5744.0%
Ribavirin2,5694.0%
Percocet2,5542.9%
Gilenya2,5513.1%
Pegasys2,5494.7%

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