These are medications for which drowsiness appears among the most-reported events in FDA adverse event reports. A report does not mean the drug caused the event. Report counts largely reflect how widely a drug is used and how often events are reported; they cannot be used to compare or rank drugs by risk. This list shows drugs where this event is among their top reported reactions, not every drug ever associated with it. This information is not medical advice. Do not stop or change a medication based on this data; discuss any concerns with your healthcare provider. Data from the FDA Adverse Event Monitoring System (AEMS), formerly FAERS, via OpenFDA.

Drowsiness or strong sleepiness during waking hours, beyond ordinary tiredness. It can make it hard to stay alert during activities like working, reading, or driving. In adverse event reports, it covers reported daytime sleepiness of any degree. Full definition in the glossary →

247 drugs meet the threshold; showing the 100 most-reported.

Medications with FDA adverse event reports of drowsiness, by report count
DrugReports of this event% of drug's total reports
Lyrica11,6914.4%
Neurontin9,4242.7%
Gralise7,6342.6%
Gabapentin7,3892.6%
Gabarone7,3892.6%
Seroquel XR7,1214.4%
Seroquel6,5874.3%
Xanax XR5,9292.9%
Xanax5,8952.9%
Klonopin5,6783.6%
Ativan5,3793.0%
Synthroid4,9991.8%
Valium4,9254.1%
Omeprazole4,8721.4%
Quetiapine Fumarate4,5464.4%
Lamictal XR4,4213.4%
Lamictal ODT4,3933.4%
Lamictal4,3923.4%
Cymbalta4,3443.2%
Risperdal4,2353.6%
Clonazepam4,1453.6%
Keppra XR4,0663.1%
Zyrtec4,0213.4%
Keppra4,0203.1%
Zyprexa Zydis3,8893.7%
Loreev XR3,8733.0%
Zyprexa Intramuscular3,8723.7%
Lorazepam3,8713.0%
Zyprexa3,8693.7%
Furosemide3,6311.4%
Lasix Onyu3,6311.4%
Katerzia3,6141.4%
Norliqva3,6141.4%
Sdamlo3,6141.4%
Valtoco3,5204.0%
Lexapro3,5152.9%
Quetiapine3,4904.6%
Quetiapine Extended Release3,4904.6%
Diazepam3,4684.0%
Abilify3,3833.0%
Xyrem3,1755.1%
Alprazolam3,1572.8%
Alprazolam Extended Release3,1572.8%
Alprazolam XR3,1572.8%
Lyrica CR3,1134.1%
Pregabalin3,1044.1%
Pregabalin Extended Release3,1044.1%
Remeron3,0413.4%
Benadryl3,0033.3%
OxyContin2,9761.4%
Claritin Reditabs2,7942.8%
Claritin Liqui-gels2,7822.8%
Claritin Allergy2,7542.8%
Claritin2,7502.8%
Baclofen (intrathecal)2,7343.2%
Topamax2,7233.0%
Lioresal (baclofen)2,6853.2%
Ozobax DS2,6853.2%
Baclofen2,6843.2%
Fleqsuvy2,6843.2%
Lyvispah2,6843.2%
Celexa2,6542.4%
Olanzapine2,6404.0%
Olanzapine Intramuscular2,6404.0%
Zoloft2,5912.5%
Sertraline2,5302.5%
Citalopram2,5162.4%
Lamotrigine2,5003.6%
Lamotrigine Extended-release2,5003.6%
Lamotrigine Kit2,5003.6%
Subvenite2,5003.6%
Mirtazapine2,4873.4%
Remeronsoltab2,4873.4%
Ingrezza2,4289.9%
Escitalopram2,4193.4%
Effexor XR2,3613.1%
Risperdal Consta2,3493.2%
Tegretol XR2,3083.6%
Ambien CR2,2822.7%
Tegretol2,2783.6%
Clozaril2,2401.8%
Zolpidem2,2223.1%
Uzedy2,2203.6%
Risperdal M-tab2,2183.6%
Perseris2,2073.6%
Risperidone2,2023.6%
Rykindo Extended-release Microspheres2,2023.6%
Ambien2,1882.7%
Effexor2,1323.1%
Venlafaxine2,1323.1%
Opium2,1112.9%
Duragesic2,1032.2%
Fentanyl2,1032.2%
Opium Tincture Deodorized2,1002.9%
Fluoxetine2,0982.7%
Levoxyl2,0731.8%
Euthyrox2,0471.9%
Bisoprolol2,0261.5%
Levetiracetam2,0072.7%
Spritam2,0072.7%

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