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Fatigue: Drugs With FDA Adverse Event Reports

825 medications where fatigue is among the most-reported events, ranked by number of reports.

These are medications for which fatigue appears among the most-reported events in FDA adverse event reports. A report does not mean the drug caused the event. Report counts largely reflect how widely a drug is used and how often events are reported; they cannot be used to compare or rank drugs by risk. This list shows drugs where this event is among their top reported reactions, not every drug ever associated with it. This information is not medical advice. Do not stop or change a medication based on this data; discuss any concerns with your healthcare provider. Data from the FDA Adverse Event Monitoring System (AEMS), formerly FAERS, via OpenFDA.

Extreme tiredness or lack of energy that does not improve with rest. Full definition in the glossary →

825 drugs meet the threshold; showing the 100 most-reported.

Medications with FDA adverse event reports of fatigue, by report count
DrugReports of this event% of drug's total reports
Deltasone40,1858.2%
Prednisone40,1848.2%
Prednisone Delayed Release40,1848.2%
Humira39,3435.6%
Vitamin D37,1179.9%
Tylenol Extra Strength34,5408.4%
Tylenol Regular Strength33,3498.5%
Methotrexate32,4236.8%
Ecotrin31,5406.2%
Bayer Low Dose31,1686.2%
Aspirin31,1396.2%
Bayer Genuine Aspirin31,1256.2%
Bayer31,1156.2%
Ecotrin Regular Strength31,1116.2%
Tri-buffered Aspirin31,1116.2%
Bayer Aspirin Regimen Chewable Low Dose Aspirin Orange31,1106.2%
Bayer Aspirin Regimen Enteric Coated31,1106.2%
Bufferin Regular Strength Pain Relief31,1106.2%
Enbrel30,4155.1%
Rasuvo29,1697.1%
Trexall29,1077.1%
Otrexup29,0937.1%
Jylamvo29,0217.1%
Xatmep29,0217.1%
Revlimid26,4346.4%
Neurontin24,5516.9%
Folic Acid23,6329.7%
Rapidol23,6327.9%
Venexa23,6329.7%
Vitrexyl23,6329.7%
Synthroid23,4068.5%
Medline23,3837.6%
Tylenol Extra Strength Caplet21,6938.2%
Gralise20,8577.2%
Excedrin Rapid Relief20,7568.2%
Lasix20,7215.3%
Panadol Extra Strength20,6948.3%
Panadol20,6938.3%
Gabapentin20,6077.2%
Gabarone20,6077.2%
Tylenol 8hr20,5858.3%
Tylenol 8 Hr Arthritis Pain20,5448.1%
Childrens Tylenol20,4538.2%
Acetaminophen20,4498.3%
Pharbetol20,4438.3%
Infants Tylenol20,4398.2%
Feverall20,4388.3%
Feverall Childrens20,4388.3%
Feverall Infants20,4388.3%
Feverall Jr. Strength20,4388.3%
Midol Long Lasting Relief20,4348.3%
Dolo-neurobion20,4338.3%
M-pap20,4338.3%
Tylenol For Children Plus Adults20,4338.3%
Omeprazole20,3606.0%
Pantoprazole Sodium20,3128.3%
Protonix20,3128.3%
Prinivil19,6106.5%
Zestril19,6106.5%
Tysabri19,51610.8%
Lisinopril18,9896.5%
Qbrelis18,9896.5%
Glucophage17,5695.0%
Metformin Hydrochloride17,5695.0%
Rituxan16,9128.2%
Maxidex16,8955.9%
Ozurdex16,8735.8%
Hemady16,8695.9%
Dexamethasone16,8655.9%
Dextenza16,8655.9%
Dexycu16,8655.9%
Advil16,7497.1%
Xeljanz XR16,7159.1%
Tylenol Cold Plus Head Congestion Severe16,38310.5%
Remicade16,2717.7%
Metoprolol16,2096.5%
Metoprolol Tartrate16,2096.5%
Katerzia15,9776.1%
Norliqva15,9776.1%
Sdamlo15,9776.1%
Ibrance15,64816.6%
Arava15,54715.1%
Lyrica15,3495.7%
Motrin Infants15,2667.2%
Actemra15,08413.9%
Metformin14,7845.0%
Pantoprazole14,7817.8%
Motrin Ib14,3927.3%
Advil Liqui-gels14,3717.2%
Orencia14,32610.6%
Zyrtec14,31912.0%
Ag-x14,3059.8%
Ibuprofen14,2547.3%
Advil Migraine14,2537.3%
Caldolor14,2427.3%
Motrin Ib Migraine14,2427.3%
Plaquenil14,06115.7%
Lipitor14,0315.8%
Zocor13,6705.5%
Ativan13,6377.7%

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