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Insomnia: Drugs With FDA Adverse Event Reports

542 medications where insomnia is among the most-reported events, ranked by number of reports.

These are medications for which insomnia appears among the most-reported events in FDA adverse event reports. A report does not mean the drug caused the event. Report counts largely reflect how widely a drug is used and how often events are reported; they cannot be used to compare or rank drugs by risk. This list shows drugs where this event is among their top reported reactions, not every drug ever associated with it. This information is not medical advice. Do not stop or change a medication based on this data; discuss any concerns with your healthcare provider. Data from the FDA Adverse Event Monitoring System (AEMS), formerly FAERS, via OpenFDA.

Difficulty falling asleep, staying asleep, or waking too early and being unable to return to sleep. Over time it can lead to daytime tiredness, irritability, and trouble concentrating. In adverse event reports, it covers reported sleep difficulty of any pattern. Full definition in the glossary →

542 drugs meet the threshold; showing the 100 most-reported.

Medications with FDA adverse event reports of insomnia, by report count
DrugReports of this event% of drug's total reports
Vitamin D11,5623.1%
Deltasone11,0822.3%
Prednisone11,0822.3%
Prednisone Delayed Release11,0822.3%
Tylenol Extra Strength10,1222.5%
Tylenol Regular Strength9,7732.5%
Lyrica9,6373.6%
Ecotrin9,4021.9%
Neurontin9,3692.6%
Bayer Low Dose9,3111.8%
Bayer Genuine Aspirin9,2781.9%
Aspirin9,2731.9%
Bayer9,2721.9%
Bayer Aspirin Regimen Chewable Low Dose Aspirin Orange9,2681.9%
Bayer Aspirin Regimen Enteric Coated9,2681.9%
Bufferin Regular Strength Pain Relief9,2681.9%
Ecotrin Regular Strength9,2681.9%
Tri-buffered Aspirin9,2681.9%
Cymbalta8,5976.3%
Seroquel XR8,2315.1%
Synthroid8,2063.0%
Medline7,5442.4%
Rapidol7,2262.4%
Xanax XR7,2233.6%
Xanax7,1793.6%
Seroquel7,1404.7%
Gralise7,1292.5%
Klonopin7,0684.5%
Gabapentin7,0222.4%
Gabarone7,0222.4%
Omeprazole6,7432.0%
Prinivil6,5942.2%
Zestril6,5942.2%
Tylenol Extra Strength Caplet6,5572.5%
Advil6,4152.7%
Excedrin Rapid Relief6,3772.5%
Ativan6,3413.6%
Lisinopril6,3402.2%
Qbrelis6,3402.2%
Panadol6,2642.5%
Panadol Extra Strength6,2642.5%
Tylenol 8 Hr Arthritis Pain6,2432.5%
Tylenol 8hr6,2232.5%
Childrens Tylenol6,1912.5%
Acetaminophen6,1772.5%
Dolo-neurobion6,1772.5%
Infants Tylenol6,1772.5%
Pharbetol6,1772.5%
Feverall6,1762.5%
Feverall Childrens6,1762.5%
Feverall Infants6,1762.5%
Feverall Jr. Strength6,1762.5%
M-pap6,1752.5%
Midol Long Lasting Relief6,1752.5%
Tylenol For Children Plus Adults6,1752.5%
Motrin Infants5,8692.8%
Pantoprazole Sodium5,6322.3%
Protonix5,6322.3%
Advil Liqui-gels5,4872.8%
Motrin Ib5,4432.7%
Chantix5,4267.1%
Advil Migraine5,4122.8%
Ibuprofen5,4032.8%
Caldolor5,3972.8%
Motrin Ib Migraine5,3972.8%
Glucophage5,3081.5%
Metformin Hydrochloride5,3081.5%
Zocor5,2472.1%
Lipitor5,0472.1%
Tylenol Cold Plus Head Congestion Severe4,8623.1%
Ambien CR4,8055.7%
Oxycodone Hydrochloride4,7942.6%
Ambien4,6205.7%
Metoprolol4,5271.8%
Metoprolol Tartrate4,5271.8%
Celebrex4,4943.5%
Metformin4,4941.5%
Clonazepam4,4613.8%
Zyrtec4,4423.7%
Katerzia4,4281.7%
Norliqva4,4261.7%
Sdamlo4,4261.7%
Ag-x4,3783.0%
Simvastatin4,2902.1%
Pantoprazole4,1962.2%
Albuterol4,1742.1%
Revlimid4,1301.0%
Loreev XR4,1093.2%
Lorazepam4,1083.2%
Zoloft4,0653.9%
Wellbutrin XL4,0594.6%
Lexapro4,0283.3%
Crestor3,9302.0%
Lunesta3,89215.5%
OxyContin3,8801.8%
Valium3,8803.3%
Vitamin C Serum3,8724.3%
Hydrochlorothiazide3,8292.7%
Inzirqo3,8292.7%
Microzide3,8292.7%

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