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Joint Pain (Arthralgia): Drugs With FDA Adverse Event Reports

685 medications where joint pain is among the most-reported events, ranked by number of reports.

These are medications for which joint pain appears among the most-reported events in FDA adverse event reports. A report does not mean the drug caused the event. Report counts largely reflect how widely a drug is used and how often events are reported; they cannot be used to compare or rank drugs by risk. This list shows drugs where this event is among their top reported reactions, not every drug ever associated with it. This information is not medical advice. Do not stop or change a medication based on this data; discuss any concerns with your healthcare provider. Data from the FDA Adverse Event Monitoring System (AEMS), formerly FAERS, via OpenFDA.

The medical term for joint pain, which can affect one joint or several, including the knees, hips, hands, or shoulders. It ranges from mild stiffness or aching to pain that limits daily movement. In adverse event reports, it covers joint pain of any severity, with or without visible swelling. Full definition in the glossary →

685 drugs meet the threshold; showing the 100 most-reported.

Medications with FDA adverse event reports of joint pain, by report count
DrugReports of this event% of drug's total reports
Humira48,3116.9%
Enbrel45,1377.6%
Methotrexate40,0408.4%
Rasuvo36,3838.9%
Trexall36,2448.9%
Otrexup36,2098.8%
Jylamvo36,1338.9%
Xatmep36,1338.9%
Deltasone32,7926.7%
Prednisone32,7916.7%
Prednisone Delayed Release32,7916.7%
Tylenol Extra Strength22,1615.4%
Tylenol Regular Strength21,6545.5%
Orencia20,71715.3%
Xeljanz XR19,81410.8%
Folic Acid19,7288.1%
Venexa19,7288.1%
Vitrexyl19,7288.1%
Vitamin D19,6725.3%
Dupixent17,6514.0%
Remicade17,2048.1%
Arava17,14216.7%
Actemra16,90415.6%
Rapidol16,3815.5%
Medline15,8855.2%
Tylenol Extra Strength Caplet14,8625.6%
Cosentyx14,6859.2%
Panadol14,4855.8%
Panadol Extra Strength14,4855.8%
Excedrin Rapid Relief14,4345.7%
Tylenol 8 Hr Arthritis Pain14,3975.7%
Tylenol 8hr14,3875.8%
Childrens Tylenol14,3195.8%
Acetaminophen14,3125.8%
Dolo-neurobion14,3115.8%
Feverall14,3105.8%
Feverall Childrens14,3105.8%
Feverall Infants14,3105.8%
Feverall Jr. Strength14,3105.8%
Pharbetol14,3095.8%
Infants Tylenol14,3085.8%
M-pap14,3085.8%
Midol Long Lasting Relief14,3085.8%
Tylenol For Children Plus Adults14,3085.8%
Xeljanz14,04913.3%
Ecotrin13,9472.7%
Bayer Low Dose13,8232.7%
Aspirin13,8102.8%
Bayer Genuine Aspirin13,8052.8%
Bayer13,8032.8%
Bayer Aspirin Regimen Chewable Low Dose Aspirin Orange13,7972.8%
Bayer Aspirin Regimen Enteric Coated13,7972.8%
Bufferin Regular Strength Pain Relief13,7972.8%
Ecotrin Regular Strength13,7972.8%
Tri-buffered Aspirin13,7972.8%
Plaquenil13,79315.4%
Azulfidine En-tabs13,30317.3%
Azulfidine13,26217.5%
Sulfasalazine13,08918.0%
Rituxan13,0746.4%
Advil12,2575.2%
Synthroid11,9764.3%
Pantoprazole Sodium11,9734.9%
Protonix11,9734.9%
Leflunomide11,71118.4%
Motrin Infants11,4455.4%
Neurontin11,2633.2%
Celebrex11,0848.6%
Omeprazole10,9093.2%
Advil Liqui-gels10,8145.4%
Motrin Ib10,8095.5%
Cimzia10,7799.4%
Advil Migraine10,7515.5%
Ibuprofen10,7475.5%
Caldolor10,7455.5%
Motrin Ib Migraine10,7455.5%
Tylenol Cold Plus Head Congestion Severe10,2126.5%
Fosamax10,20012.5%
Ag-x9,7546.7%
Simponi9,68212.1%
Prinivil9,4693.1%
Zestril9,4693.1%
Lyrica9,3813.5%
Gralise9,3673.2%
Hydroxychloroquine9,35012.8%
Gabapentin9,3233.3%
Gabarone9,3233.3%
Lisinopril9,1173.1%
Qbrelis9,1173.1%
Glucophage9,0122.6%
Metformin Hydrochloride9,0122.6%
Diclofenac8,81510.5%
Diclofenac Sodium8,81510.5%
Voltaren8,81510.5%
Lasix8,6822.2%
Forteo8,6727.8%
Naproxen8,6429.9%
Lipitor8,5983.5%
Pantoprazole8,5534.5%
Hydroxychloroquine Sulfate8,37621.4%

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