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Swelling (Peripheral Swelling): Drugs With FDA Adverse Event Reports

249 medications where swelling is among the most-reported events, ranked by number of reports.

These are medications for which swelling appears among the most-reported events in FDA adverse event reports. A report does not mean the drug caused the event. Report counts largely reflect how widely a drug is used and how often events are reported; they cannot be used to compare or rank drugs by risk. This list shows drugs where this event is among their top reported reactions, not every drug ever associated with it. This information is not medical advice. Do not stop or change a medication based on this data; discuss any concerns with your healthcare provider. Data from the FDA Adverse Event Monitoring System (AEMS), formerly FAERS, via OpenFDA.

Swelling in the arms, legs, hands, or feet, often from fluid buildup. Full definition in the glossary →

249 drugs meet the threshold; showing the 100 most-reported.

Medications with FDA adverse event reports of swelling, by report count
DrugReports of this event% of drug's total reports
Humira15,3372.2%
Methotrexate14,7443.1%
Deltasone14,5593.0%
Prednisone14,5593.0%
Prednisone Delayed Release14,5593.0%
Enbrel14,2292.4%
Rasuvo13,3413.2%
Otrexup13,3153.3%
Trexall13,2833.3%
Jylamvo13,2813.3%
Xatmep13,2813.3%
Tylenol Extra Strength10,7462.6%
Tylenol Regular Strength10,4862.7%
Xeljanz XR9,7605.3%
Vitamin D9,3002.5%
Arava9,2869.0%
Actemra8,7028.0%
Lasix8,3262.1%
Folic Acid8,2253.4%
Venexa8,2253.4%
Vitrexyl8,2253.4%
Orencia8,1716.0%
Medline8,1092.6%
Rapidol8,0142.7%
Tylenol Extra Strength Caplet7,5762.8%
Pantoprazole Sodium7,4783.0%
Protonix7,4783.0%
Panadol Extra Strength7,3763.0%
Panadol7,3753.0%
Excedrin Rapid Relief7,3482.9%
Tylenol 8 Hr Arthritis Pain7,3352.9%
Tylenol 8hr7,3302.9%
Xeljanz7,3166.9%
Acetaminophen7,2942.9%
Pharbetol7,2942.9%
Childrens Tylenol7,2922.9%
Dolo-neurobion7,2903.0%
Feverall7,2902.9%
Feverall Childrens7,2902.9%
Feverall Infants7,2902.9%
Feverall Jr. Strength7,2902.9%
Infants Tylenol7,2902.9%
M-pap7,2903.0%
Midol Long Lasting Relief7,2903.0%
Tylenol For Children Plus Adults7,2903.0%
Leflunomide6,90410.9%
Plaquenil6,8717.7%
Revlimid6,6781.6%
Azulfidine En-tabs6,6058.6%
Azulfidine6,6038.7%
Sulfasalazine6,5639.0%
Remicade6,4993.1%
Rituxan6,4973.2%
Advil6,2382.6%
Cimzia6,0715.3%
Simponi5,9877.5%
Neurontin5,8261.6%
Motrin Infants5,8002.7%
Oxycodone Hydrochloride5,7533.2%
Motrin Ib5,6542.9%
Advil Liqui-gels5,6282.8%
Advil Migraine5,6232.9%
Ibuprofen5,6232.9%
Caldolor5,6202.9%
Motrin Ib Migraine5,6202.9%
Hydroxychloroquine5,5637.6%
Tylenol Cold Plus Head Congestion Severe5,5193.5%
Lyrica5,4972.1%
Cosentyx5,3913.4%
Pantoprazole5,3832.8%
Gralise5,2911.8%
Katerzia5,2712.0%
Norliqva5,2712.0%
Sdamlo5,2712.0%
Gabapentin5,2151.8%
Gabarone5,2151.8%
Furosemide5,0342.0%
Lasix Onyu5,0342.0%
Cetirizine5,0147.5%
Cetirizine Hydrochloride5,0147.5%
Omeprazole4,9951.5%
Diclofenac Sodium4,8735.8%
Diclofenac4,8725.8%
Voltaren4,8725.8%
Xtampza ER4,7334.5%
Qbrelis4,6931.6%
Lisinopril4,6921.6%
Fosamax4,6215.6%
Synthroid4,5401.6%
Hydroxychloroquine Sulfate4,50311.5%
Sovuna4,50311.5%
Naproxen4,2014.8%
Celebrex4,0993.2%
Protonix Delayed-release4,0472.8%
Letairis4,0083.2%
Metoprolol3,8821.6%
Metoprolol Tartrate3,8821.6%
Losartan Potassium3,8622.3%
Voltaren Arthritis Pain3,6293.7%
Vitamin C Serum3,4603.9%

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