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Weight Gain (Weight Increased): Drugs With FDA Adverse Event Reports

483 medications where weight gain is among the most-reported events, ranked by number of reports.

These are medications for which weight gain appears among the most-reported events in FDA adverse event reports. A report does not mean the drug caused the event. Report counts largely reflect how widely a drug is used and how often events are reported; they cannot be used to compare or rank drugs by risk. This list shows drugs where this event is among their top reported reactions, not every drug ever associated with it. This information is not medical advice. Do not stop or change a medication based on this data; discuss any concerns with your healthcare provider. Data from the FDA Adverse Event Monitoring System (AEMS), formerly FAERS, via OpenFDA.

Gaining body weight without intending to. Reports range from gradual changes over months to more rapid gains, and can involve fluid retention as well as body mass. In adverse event reports, it reflects weight gain the patient or clinician considered noteworthy. Full definition in the glossary →

483 drugs meet the threshold; showing the 100 most-reported.

Medications with FDA adverse event reports of weight gain, by report count
DrugReports of this event% of drug's total reports
Deltasone17,2553.5%
Prednisone17,2553.5%
Prednisone Delayed Release17,2553.5%
Methotrexate11,7752.5%
Tylenol Extra Strength11,7512.9%
Tylenol Regular Strength11,5132.9%
Lyrica11,4984.3%
Rasuvo11,0152.7%
Trexall10,9972.7%
Otrexup10,9962.7%
Jylamvo10,9882.7%
Xatmep10,9882.7%
Rapidol9,7943.3%
Vitamin D9,5932.6%
Medline9,4883.1%
Remicade8,9504.2%
Tylenol Extra Strength Caplet8,8743.3%
Risperdal8,8207.4%
Panadol8,7173.5%
Panadol Extra Strength8,7173.5%
Excedrin Rapid Relief8,6853.4%
Tylenol 8 Hr Arthritis Pain8,6583.4%
Tylenol 8hr8,6563.5%
Childrens Tylenol8,6413.5%
Acetaminophen8,6273.5%
Feverall8,6273.5%
Feverall Childrens8,6273.5%
Feverall Infants8,6273.5%
Feverall Jr. Strength8,6273.5%
Pharbetol8,6273.5%
Dolo-neurobion8,6263.5%
Infants Tylenol8,6263.5%
M-pap8,6263.5%
Midol Long Lasting Relief8,6263.5%
Tylenol For Children Plus Adults8,6263.5%
Folic Acid8,4453.5%
Venexa8,4453.5%
Vitrexyl8,4453.5%
Synthroid7,8052.8%
Pantoprazole Sodium7,4893.0%
Protonix7,4893.0%
Abilify7,3876.5%
Lasix7,3501.9%
Actemra7,2446.7%
Neurontin6,8891.9%
Zyprexa Zydis6,7806.5%
Zyprexa6,7036.4%
Zyprexa Intramuscular6,7036.4%
Seroquel XR6,6164.1%
Rituxan6,6143.2%
Xeljanz XR6,2983.4%
Arava6,0885.9%
Seroquel6,0714.0%
Glucophage5,9551.7%
Metformin Hydrochloride5,9551.7%
Advil5,8832.5%
Oxycodone Hydrochloride5,5823.1%
Motrin Infants5,5402.6%
Prinivil5,3901.8%
Zestril5,3881.8%
Orencia5,3564.0%
Advil Liqui-gels5,2772.7%
Motrin Ib5,2612.7%
Tylenol Cold Plus Head Congestion Severe5,2523.4%
Pantoprazole5,2462.8%
Ibuprofen5,2402.7%
Advil Migraine5,2382.7%
Caldolor5,2372.7%
Motrin Ib Migraine5,2372.7%
Renflexis5,2249.1%
Gralise5,1801.8%
Infliximab5,1799.3%
Xeljanz5,1714.9%
Qbrelis5,1351.8%
Lisinopril5,1331.8%
Metformin5,1081.7%
Gabapentin5,0641.8%
Gabarone5,0641.8%
Plaquenil4,9905.6%
Azulfidine En-tabs4,9276.4%
Azulfidine4,9236.5%
Sulfasalazine4,8966.7%
Cetirizine4,8677.3%
Cetirizine Hydrochloride4,8677.3%
Ativan4,8162.7%
Cimzia4,8154.2%
Risperdal Consta4,8006.5%
Leflunomide4,7907.5%
Diclofenac4,7265.6%
Diclofenac Sodium4,7265.6%
Voltaren4,7265.6%
Fosamax4,6985.7%
Quality Choice4,6624.2%
Simponi4,5635.7%
Xtampza ER4,5544.3%
Klonopin4,5462.9%
Zyrtec4,5113.8%
Protonix Delayed-release4,4573.1%
Risperdal M-tab4,3987.1%
Ag-x4,3513.0%

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