Eliquisapixaban
According to the FDA label: ELIQUIS is a factor Xa inhibitor indicated: to reduce the risk of stroke and systemic embolism in patients with nonvalvular atrial fibrillation. (1.1) for the prophylaxis of deep vein thrombosis (DVT), which may lead to pulmonary embolism (PE), in patients who have undergone hip or knee replacement surgery. (1.2) for the treatment of DVT and PE, and for the reduction in the risk of recurrent DVT and PE following initial therapy.
64,339 adverse event reports submitted to the FDA (2005–2026)
Top Reported Adverse Events
The most frequently reported events in association with Eliquis in the FAERS database. These are events reported by patients taking this medication, not necessarily caused by it. A single report may include multiple events.
Show these terms with plain-language definitions
Tap any term below for a plain-language definition.
Atrial Fibrillation 4,015 reports
An irregular, often rapid heart rhythm.
Full definition in the glossary →Dyspnoea 3,663 reports
Shortness of breath or difficulty breathing. Also spelled dyspnea in American English.
Full definition in the glossary → See all drugs reporting this event →Cerebrovascular Accident 3,540 reports
The medical term for a stroke, which happens when blood flow to part of the brain is interrupted.
Full definition in the glossary →Thrombosis 2,831 reports
The formation of a blood clot inside a blood vessel.
Full definition in the glossary →Off Label Use 2,767 reports
Using a medication for a condition or in a way that the FDA has not officially approved. This is common and often legal, and a report of it does not mean something went wrong. Doctors sometimes prescribe drugs off label based on their judgment.
Full definition in the glossary →Cardiac Disorder 2,513 reports
A general report of a problem with the heart, used when no more specific condition is named.
Full definition in the glossary →Death 2,371 reports
A report that the person died. A death appearing in reports for a drug does not mean the drug caused it. Reports record that a death occurred while the medication was being used, which can happen for many unrelated reasons.
Full definition in the glossary →Fall 2,355 reports
A report that the person fell down. Falls are tracked because they can signal issues like dizziness, weakness, or balance problems.
Full definition in the glossary →Fatigue 2,262 reports
Extreme tiredness or lack of energy that does not improve with rest.
Full definition in the glossary → See all drugs reporting this event →Dizziness 1,987 reports
A feeling of being lightheaded, unsteady, or like the room is spinning.
Full definition in the glossary → See all drugs reporting this event →Anaemia 1,979 reports
A condition where there are too few healthy red blood cells to carry enough oxygen, often causing tiredness and paleness. Also spelled anemia in American English.
Full definition in the glossary → See all drugs reporting this event →Diarrhoea 1,825 reports
Loose or watery bowel movements, often frequent. Also spelled diarrhea in American English.
Full definition in the glossary → See all drugs reporting this event →Nausea 1,743 reports
The feeling of sickness in your stomach that often comes before vomiting.
Full definition in the glossary → See all drugs reporting this event →Acute Kidney Injury 1,726 reports
A sudden drop in how well the kidneys are working. It is often temporary and can have many causes.
Full definition in the glossary →Drug Ineffective 1,705 reports
A report that the medication did not work as expected for the person taking it. This is a reporting category, not a sign the drug is defective. It simply means someone felt it was not helping their condition.
Full definition in the glossary →
Ranked by frequency of reports, not severity. The most-reported event is not necessarily the most dangerous or the most common in patients taking this drug.
Who Is Reporting
Demographics of patients in FAERS reports that included this information. Not all reports include patient demographics.
By Sex
View reporter sex data as a table
| Sex | Reports |
|---|---|
| Male | 31,478 |
| Female | 27,642 |
| Unknown | 20 |
By Age Group
View age group data as a table
| Age group | Reports |
|---|---|
| 0-17 | 487 |
| 18-34 | 895 |
| 35-49 | 1,899 |
| 50-64 | 7,587 |
| 65-74 | 12,654 |
| 75+ | 21,780 |
This shows who filed reports, reflecting who takes this drug and who tends to report, not who is at greatest risk.
Reported Outcomes
Outcomes recorded in FAERS reports that included Eliquis. A single report may involve multiple reactions, each with a different outcome. These categories are defined by FDA reporting guidelines, not by PillSignal.
View outcome data as a table
| Outcome | Reports |
|---|---|
| Other Serious | 47,152 |
| Hospitalization | 28,251 |
| Death | 6,997 |
| Life-Threatening | 4,894 |
| Non-Serious | 2,804 |
| Disability | 1,845 |
Serious outcomes are far more likely to be reported than mild ones, so this overstates how often outcomes are serious. A recorded death does not mean the drug caused it.
Report Volume Over Time
Number of FAERS reports received per quarter for Eliquis. Changes in volume may reflect shifts in prescribing rates, media attention, or reporting behavior, not changes in the medication's safety profile.
View report trend as a table
| Year | Reports |
|---|---|
| 2005 | 1 |
| 2007 | 2 |
| 2008 | 7 |
| 2009 | 19 |
| 2010 | 35 |
| 2011 | 112 |
| 2012 | 18 |
| 2013 | 87 |
| 2014 | 257 |
| 2015 | 1,011 |
| 2016 | 1,808 |
| 2017 | 2,608 |
| 2018 | 3,928 |
| 2019 | 5,241 |
| 2020 | 10,945 |
| 2021 | 14,688 |
| 2022 | 5,624 |
| 2023 | 4,769 |
| 2024 | 5,705 |
| 2025 | 5,874 |
| 2026 (partial) | 1,600 |
The steep increase around 2004 reflects the FDA's move to electronic submission, not a change in this drug's safety. Trends track reporting volume, not risk.
Medications commonly reported with Eliquis
In FDA adverse event reports that mention Eliquis, these medications appeared most often in the same report.
- Bisoprolol (7,668 reports)
- Furosemide (7,226 reports)
- Pantoprazole (4,887 reports)
- Metoprolol (4,619 reports)
- Omeprazole (3,817 reports)
This reflects co-occurrence in submitted reports, not evidence of drug interaction or combined risk. People often report several medications taken for the same condition or for unrelated reasons. Talk to a doctor or pharmacist about your specific medications.
Related Drugs
Other medications with similar adverse event profiles in FDA FAERS reports.
Data Source
This data is sourced from the FDA's Adverse Event Monitoring System (AEMS), formerly FAERS, via the OpenFDA API. PillSignal is not affiliated with the FDA.
View this data on the FDA website →Data last updated: June 2026