Exjadedeferasirox
According to the FDA label: Deferasirox tablets are an iron chelator indicated for the treatment of chronic iron overload due to blood transfusions in patients 2 years of age and older.
22,718 adverse event reports submitted to the FDA (2005–2026)
Top Reported Adverse Events
The most frequently reported events in association with Exjade in the FAERS database. These are events reported by patients taking this medication, not necessarily caused by it. A single report may include multiple events.
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Death 4,225 reports
A report that the person died. A death appearing in reports for a drug does not mean the drug caused it. Reports record that a death occurred while the medication was being used, which can happen for many unrelated reasons.
Full definition in the glossary →Diarrhoea 2,071 reports
Loose or watery bowel movements, often frequent. Also spelled diarrhea in American English.
Full definition in the glossary → See all drugs reporting this event →- Sickle Cell Anaemia With Crisis 1,607 reports
Pyrexia 1,353 reports
The medical term for fever, meaning a raised body temperature.
Full definition in the glossary → See all drugs reporting this event →Nausea 1,247 reports
The feeling of sickness in your stomach that often comes before vomiting.
Full definition in the glossary → See all drugs reporting this event →Haemoglobin Decreased 1,245 reports
A blood test result showing a low level of haemoglobin, the protein in red blood cells that carries oxygen. This is closely related to anaemia. Also spelled hemoglobin in American English.
Full definition in the glossary →Pneumonia 1,150 reports
An infection that inflames the air sacs in the lungs, which can cause cough, fever, and difficulty breathing.
Full definition in the glossary →- Serum Ferritin Increased 1,067 reports
Malaise 1,019 reports
A general feeling of being unwell or uncomfortable, without a specific symptom.
Full definition in the glossary →Vomiting 996 reports
Throwing up the contents of the stomach.
Full definition in the glossary → See all drugs reporting this event →Fatigue 972 reports
Extreme tiredness or lack of energy that does not improve with rest.
Full definition in the glossary → See all drugs reporting this event →Abdominal Pain 823 reports
Pain in the belly or stomach area.
Full definition in the glossary → See all drugs reporting this event →Pain 823 reports
A general report of physical discomfort, used when no more specific location is given.
Full definition in the glossary →Blood Creatinine Increased 768 reports
A blood test result showing a higher than normal level of creatinine, which can be a sign the kidneys are not filtering as well as usual.
Full definition in the glossary →Platelet Count Decreased 730 reports
A blood test result showing a low level of platelets, the cells that help blood clot. This is the lab-measurement version of thrombocytopenia.
Full definition in the glossary →
Ranked by frequency of reports, not severity. The most-reported event is not necessarily the most dangerous or the most common in patients taking this drug.
Who Is Reporting
Demographics of patients in FAERS reports that included this information. Not all reports include patient demographics.
By Sex
View reporter sex data as a table
| Sex | Reports |
|---|---|
| Male | 10,709 |
| Female | 10,116 |
| Unknown | 75 |
By Age Group
View age group data as a table
| Age group | Reports |
|---|---|
| 0-17 | 1,512 |
| 18-34 | 1,527 |
| 35-49 | 1,204 |
| 50-64 | 1,631 |
| 65-74 | 2,009 |
| 75+ | 2,516 |
This shows who filed reports, reflecting who takes this drug and who tends to report, not who is at greatest risk.
Reported Outcomes
Outcomes recorded in FAERS reports that included Exjade. A single report may involve multiple reactions, each with a different outcome. These categories are defined by FDA reporting guidelines, not by PillSignal.
View outcome data as a table
| Outcome | Reports |
|---|---|
| Other Serious | 9,358 |
| Hospitalization | 8,975 |
| Death | 7,059 |
| Non-Serious | 2,140 |
| Life-Threatening | 763 |
| Disability | 313 |
Serious outcomes are far more likely to be reported than mild ones, so this overstates how often outcomes are serious. A recorded death does not mean the drug caused it.
Report Volume Over Time
Number of FAERS reports received per quarter for Exjade. Changes in volume may reflect shifts in prescribing rates, media attention, or reporting behavior, not changes in the medication's safety profile.
View report trend as a table
| Year | Reports |
|---|---|
| 2005 | 1 |
| 2006 | 380 |
| 2007 | 336 |
| 2008 | 402 |
| 2009 | 2,044 |
| 2010 | 2,487 |
| 2011 | 3,027 |
| 2012 | 2,694 |
| 2013 | 831 |
| 2014 | 1,693 |
| 2015 | 2,168 |
| 2016 | 1,311 |
| 2017 | 941 |
| 2018 | 750 |
| 2019 | 559 |
| 2020 | 553 |
| 2021 | 552 |
| 2022 | 656 |
| 2023 | 458 |
| 2024 | 453 |
| 2025 | 372 |
| 2026 (partial) | 50 |
The steep increase around 2004 reflects the FDA's move to electronic submission, not a change in this drug's safety. Trends track reporting volume, not risk.
Medications commonly reported with Exjade
In FDA adverse event reports that mention Exjade, these medications appeared most often in the same report.
- Folic Acid (1,721 reports)
- Furosemide (918 reports)
- Hydroxyurea (810 reports)
- Aspirin (696 reports)
- Lenalidomide (646 reports)
This reflects co-occurrence in submitted reports, not evidence of drug interaction or combined risk. People often report several medications taken for the same condition or for unrelated reasons. Talk to a doctor or pharmacist about your specific medications.
Related Drugs
Other medications with similar adverse event profiles in FDA FAERS reports.
Data Source
This data is sourced from the FDA's Adverse Event Monitoring System (AEMS), formerly FAERS, via the OpenFDA API. PillSignal is not affiliated with the FDA.
View this data on the FDA website →Data last updated: June 2026