Metoclopramide
According to the FDA label: Diabetic Gastroparesis (Diabetic Gastric Stasis) Metoclopramide is indicated for the relief of symptoms associated with acute and recurrent diabetic gastric stasis. The Prevention of Nausea and Vomiting Associated with Emetogenic Cancer Chemotherapy Metoclopramide Injection, USP is indicated for the prophylaxis of vomiting associated with emetogenic cancer chemotherapy.
61,564 adverse event reports submitted to the FDA (1995–2026)
Top Reported Adverse Events
The most frequently reported events in association with Metoclopramide in the FAERS database. These are events reported by patients taking this medication, not necessarily caused by it. A single report may include multiple events.
Show these terms with plain-language definitions
Tap any term below for a plain-language definition.
- Tardive Dyskinesia 15,392 reports
Extrapyramidal Disorder 12,507 reports
A group of movement problems, such as stiffness, tremor, or restlessness, that can be associated with certain medications.
Full definition in the glossary →- Nervous System Disorder 7,402 reports
Dystonia 6,980 reports
Involuntary muscle contractions that cause twisting movements or abnormal postures.
Full definition in the glossary →Pain 5,008 reports
A general report of physical discomfort, used when no more specific location is given.
Full definition in the glossary →Nausea 4,679 reports
The feeling of sickness in your stomach that often comes before vomiting.
Full definition in the glossary → See all drugs reporting this event →Economic Problem 3,807 reports
A report noting a financial difficulty, such as trouble affording a medication. This is a non-medical category sometimes recorded in reports.
Full definition in the glossary →Vomiting 3,623 reports
Throwing up the contents of the stomach.
Full definition in the glossary → See all drugs reporting this event →Anxiety 3,315 reports
A feeling of worry, nervousness, or unease.
Full definition in the glossary → See all drugs reporting this event →Incorrect Drug Administration Duration 3,177 reports
A report that a medication was taken for a longer or shorter time than directed. This is a usage category.
Full definition in the glossary →Diarrhoea 3,159 reports
Loose or watery bowel movements, often frequent. Also spelled diarrhea in American English.
Full definition in the glossary → See all drugs reporting this event →- Movement Disorder 3,061 reports
Dyskinesia 2,840 reports
Involuntary, uncontrolled movements of the body.
Full definition in the glossary →- Activities Of Daily Living Impaired 2,815 reports
Off Label Use 2,538 reports
Using a medication for a condition or in a way that the FDA has not officially approved. This is common and often legal, and a report of it does not mean something went wrong. Doctors sometimes prescribe drugs off label based on their judgment.
Full definition in the glossary →
Ranked by frequency of reports, not severity. The most-reported event is not necessarily the most dangerous or the most common in patients taking this drug.
Who Is Reporting
Demographics of patients in FAERS reports that included this information. Not all reports include patient demographics.
By Sex
View reporter sex data as a table
| Sex | Reports |
|---|---|
| Female | 34,226 |
| Male | 21,200 |
| Unknown | 1,501 |
By Age Group
View age group data as a table
| Age group | Reports |
|---|---|
| 0-17 | 1,736 |
| 18-34 | 3,321 |
| 35-49 | 5,477 |
| 50-64 | 10,704 |
| 65-74 | 8,415 |
| 75+ | 5,509 |
This shows who filed reports, reflecting who takes this drug and who tends to report, not who is at greatest risk.
Reported Outcomes
Outcomes recorded in FAERS reports that included Metoclopramide. A single report may involve multiple reactions, each with a different outcome. These categories are defined by FDA reporting guidelines, not by PillSignal.
View outcome data as a table
| Outcome | Reports |
|---|---|
| Other Serious | 35,398 |
| Hospitalization | 28,049 |
| Disability | 13,363 |
| Death | 8,197 |
| Life-Threatening | 4,724 |
| Non-Serious | 3,738 |
Serious outcomes are far more likely to be reported than mild ones, so this overstates how often outcomes are serious. A recorded death does not mean the drug caused it.
Report Volume Over Time
Number of FAERS reports received per quarter for Metoclopramide. Changes in volume may reflect shifts in prescribing rates, media attention, or reporting behavior, not changes in the medication's safety profile.
View report trend as a table
| Year | Reports |
|---|---|
| 1995 | 1 |
| 1997 | 1 |
| 1999 | 5 |
| 2001 | 1 |
| 2003 | 6 |
| 2004 | 676 |
| 2005 | 707 |
| 2006 | 652 |
| 2007 | 629 |
| 2008 | 789 |
| 2009 | 1,011 |
| 2010 | 1,961 |
| 2011 | 11,197 |
| 2012 | 6,516 |
| 2013 | 2,131 |
| 2014 | 1,785 |
| 2015 | 1,808 |
| 2016 | 2,109 |
| 2017 | 1,883 |
| 2018 | 3,009 |
| 2019 | 3,377 |
| 2020 | 3,234 |
| 2021 | 3,854 |
| 2022 | 3,894 |
| 2023 | 3,528 |
| 2024 | 3,176 |
| 2025 | 2,941 |
| 2026 (partial) | 683 |
The steep increase around 2004 reflects the FDA's move to electronic submission, not a change in this drug's safety. Trends track reporting volume, not risk.
Medications commonly reported with Metoclopramide
In FDA adverse event reports that mention Metoclopramide, these medications appeared most often in the same report.
- Ondansetron (10,696 reports)
- Acetaminophen (9,193 reports)
- Dexamethasone (8,827 reports)
- Omeprazole (7,965 reports)
- Pantoprazole (7,414 reports)
This reflects co-occurrence in submitted reports, not evidence of drug interaction or combined risk. People often report several medications taken for the same condition or for unrelated reasons. Talk to a doctor or pharmacist about your specific medications.
Related Drugs
Other medications with similar adverse event profiles in FDA FAERS reports.
Data Source
This data is sourced from the FDA's Adverse Event Monitoring System (AEMS), formerly FAERS, via the OpenFDA API. PillSignal is not affiliated with the FDA.
View this data on the FDA website →Data last updated: June 2026