Sensiparcinacalcet
According to the FDA label: Cinacalcet is a positive modulator of the calcium sensing receptor indicated for: Secondary Hyperparathyroidism (HPT) in adult patients with chronic kidney disease (CKD) on dialysis. ( 1.1 ) Limitations of Use : Cinacalcet tablets are not indicated for use in patients with CKD who are not on dialysis Hypercalcemia in adult patients with Parathyroid Carcinoma (PC).
46,275 adverse event reports submitted to the FDA (2004–2026)
Top Reported Adverse Events
The most frequently reported events in association with Sensipar in the FAERS database. These are events reported by patients taking this medication, not necessarily caused by it. A single report may include multiple events.
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Drug Dose Omission 8,738 reports
A report that a dose of medication was missed or skipped.
Full definition in the glossary →Hospitalisation 6,928 reports
A report that the person was admitted to a hospital. This records that a hospital stay occurred, which is one way the seriousness of an event is tracked. Also spelled hospitalization in American English.
Full definition in the glossary →- Laboratory Test Abnormal 4,222 reports
Off Label Use 2,498 reports
Using a medication for a condition or in a way that the FDA has not officially approved. This is common and often legal, and a report of it does not mean something went wrong. Doctors sometimes prescribe drugs off label based on their judgment.
Full definition in the glossary →Nausea 2,284 reports
The feeling of sickness in your stomach that often comes before vomiting.
Full definition in the glossary → See all drugs reporting this event →Intentional Product Misuse 2,084 reports
A report that a medication was deliberately used in a way other than directed. This is a usage category describing what happened, not a judgment.
Full definition in the glossary →Death 1,830 reports
A report that the person died. A death appearing in reports for a drug does not mean the drug caused it. Reports record that a death occurred while the medication was being used, which can happen for many unrelated reasons.
Full definition in the glossary →Malaise 1,562 reports
A general feeling of being unwell or uncomfortable, without a specific symptom.
Full definition in the glossary →Vomiting 1,546 reports
Throwing up the contents of the stomach.
Full definition in the glossary → See all drugs reporting this event →Adverse Drug Reaction 1,460 reports
A general report of a harmful or unintended response to a medication, used when no more specific reaction is named.
Full definition in the glossary →Diarrhoea 1,125 reports
Loose or watery bowel movements, often frequent. Also spelled diarrhea in American English.
Full definition in the glossary → See all drugs reporting this event →Decreased Appetite 828 reports
Abdominal Discomfort 775 reports
A general unease or mild pain in the belly area.
Full definition in the glossary →Muscle Spasms 600 reports
Sudden, involuntary tightening of a muscle, often called cramps.
Full definition in the glossary → See all drugs reporting this event →Hypotension 574 reports
Ranked by frequency of reports, not severity. The most-reported event is not necessarily the most dangerous or the most common in patients taking this drug.
Who Is Reporting
Demographics of patients in FAERS reports that included this information. Not all reports include patient demographics.
By Sex
View reporter sex data as a table
| Sex | Reports |
|---|---|
| Female | 21,961 |
| Male | 19,019 |
| Unknown | 221 |
By Age Group
View age group data as a table
| Age group | Reports |
|---|---|
| 0-17 | 122 |
| 18-34 | 1,605 |
| 35-49 | 5,161 |
| 50-64 | 10,336 |
| 65-74 | 6,040 |
| 75+ | 4,056 |
This shows who filed reports, reflecting who takes this drug and who tends to report, not who is at greatest risk.
Reported Outcomes
Outcomes recorded in FAERS reports that included Sensipar. A single report may involve multiple reactions, each with a different outcome. These categories are defined by FDA reporting guidelines, not by PillSignal.
View outcome data as a table
| Outcome | Reports |
|---|---|
| Non-Serious | 29,358 |
| Hospitalization | 11,052 |
| Other Serious | 10,661 |
| Death | 2,515 |
| Disability | 494 |
| Life-Threatening | 287 |
Serious outcomes are far more likely to be reported than mild ones, so this overstates how often outcomes are serious. A recorded death does not mean the drug caused it.
Report Volume Over Time
Number of FAERS reports received per quarter for Sensipar. Changes in volume may reflect shifts in prescribing rates, media attention, or reporting behavior, not changes in the medication's safety profile.
View report trend as a table
| Year | Reports |
|---|---|
| 2004 | 104 |
| 2005 | 127 |
| 2006 | 221 |
| 2007 | 121 |
| 2008 | 269 |
| 2009 | 317 |
| 2010 | 399 |
| 2011 | 508 |
| 2012 | 531 |
| 2013 | 789 |
| 2014 | 1,009 |
| 2015 | 7,880 |
| 2016 | 7,587 |
| 2017 | 10,651 |
| 2018 | 12,675 |
| 2019 | 772 |
| 2020 | 388 |
| 2021 | 329 |
| 2022 | 446 |
| 2023 | 413 |
| 2024 | 422 |
| 2025 | 285 |
| 2026 (partial) | 32 |
The steep increase around 2004 reflects the FDA's move to electronic submission, not a change in this drug's safety. Trends track reporting volume, not risk.
Medications commonly reported with Sensipar
In FDA adverse event reports that mention Sensipar, these medications appeared most often in the same report.
- Sevelamer Carbonate (1,134 reports)
- Aspirin (1,105 reports)
- Omeprazole (1,010 reports)
- Furosemide (951 reports)
- Metoprolol (883 reports)
This reflects co-occurrence in submitted reports, not evidence of drug interaction or combined risk. People often report several medications taken for the same condition or for unrelated reasons. Talk to a doctor or pharmacist about your specific medications.
Related Drugs
Other medications with similar adverse event profiles in FDA FAERS reports.
Data Source
This data is sourced from the FDA's Adverse Event Monitoring System (AEMS), formerly FAERS, via the OpenFDA API. PillSignal is not affiliated with the FDA.
View this data on the FDA website →Data last updated: June 2026