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Acid Reflux (Gastrooesophageal Reflux Disease): Drugs With FDA Adverse Event Reports

72 medications where acid reflux is among the most-reported events, ranked by number of reports.

These are medications for which acid reflux appears among the most-reported events in FDA adverse event reports. A report does not mean the drug caused the event. Report counts largely reflect how widely a drug is used and how often events are reported; they cannot be used to compare or rank drugs by risk. This list shows drugs where this event is among their top reported reactions, not every drug ever associated with it. This information is not medical advice. Do not stop or change a medication based on this data; discuss any concerns with your healthcare provider. Data from the FDA Adverse Event Monitoring System (AEMS), formerly FAERS, via OpenFDA.

A condition, often called acid reflux or GERD, where stomach acid flows back into the food pipe, causing heartburn. Also spelled gastroesophageal in American English. Full definition in the glossary →

Medications with FDA adverse event reports of acid reflux, by report count
DrugReports of this event% of drug's total reports
Nexium10,9916.0%
Omeprazole5,3361.6%
Prilosec4,6344.4%
Protonix Delayed-release4,2552.9%
Prevacid4,1182.4%
Prevacid 24 Hr2,4522.0%
Singulair2,4232.0%
Tums Ultra2,4073.9%
Tums Ex2,3773.8%
Tums Regular Strength2,3713.8%
Tums2,3653.8%
Tums Chewy Delights2,3653.8%
Tums Extra Strength Sugar-free2,3653.8%
Tums Extra Strength, Smoothies2,3653.8%
Tums Naturals2,3653.8%
Tums Smoothies2,3653.8%
ProAir HFA2,2671.9%
Nexium 24hr2,2485.4%
Ranitidine2,2251.1%
Ranitidine Cool Mint2,2251.1%
Pepcid2,1322.1%
Benicar2,0765.9%
Prilosec Otc1,9486.4%
Topamax1,6501.8%
Pepcid Ac Maximum Strength1,5602.0%
Pepcid Ac1,5562.0%
Pepcid Ac Original Strength1,5562.0%
Nasonex1,5264.8%
Esomeprazole1,5202.5%
Esomeprazole Magnesium1,5202.5%
Montelukast Sodium1,5031.9%
Nucala1,4573.0%
Dexilant1,4403.5%
Zantac 3601,4151.8%
Equate Famotidine1,3041.8%
Famotidine1,3041.8%
Aimovig1,2272.3%
Pulmicort1,1902.1%
Rhinocort1,1902.1%
Amoxicillin1,1891.6%
Amoxil1,1891.6%
Riopan1,1112.4%
Flexeril1,1082.3%
Good Sense Esomeprazole Magnesium1,1062.4%
Pulmicort Flexhaler1,0982.3%
Tarpeyo1,0322.3%
Colace1,0102.0%
Xyrem8241.3%
Atrovent HFA8172.3%
Imodium A-d7821.8%
Loratadine7401.5%
Zepbound6651.2%
Zepbound Kwikpen6651.2%
Imodium Multi-symptom Relief6632.1%
Ranitidine Hydrochloride6621.2%
Byetta6591.3%
Aciphex6502.4%
Esbriet6251.6%
Strattera5972.5%
Victoza4741.1%
Keflex4472.1%
Zanaflex4402.5%
Zithromax3712.0%
Cytomel3524.1%
Desyrel3322.2%
Retin-A3144.2%
Bentyl2631.9%
Evista2051.4%
Detrol1701.9%
Prempro1490.6%
Oxymorphone Hydrochloride940.8%
Rybelsus841.2%

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