Aimovigerenumab
According to the FDA label: AIMOVIG is indicated for the preventive treatment of migraine in adults. AIMOVIG is a calcitonin gene-related peptide receptor antagonist indicated for the preventive treatment of migraine in adults. ( 1 )
53,871 adverse event reports submitted to the FDA (2009–2026)
Top Reported Adverse Events
The most frequently reported events in association with Aimovig in the FAERS database. These are events reported by patients taking this medication, not necessarily caused by it. A single report may include multiple events.
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Accidental Exposure to Product 10,103 reports
A report that someone was unintentionally exposed to a medication, for example a child or another person who was not the patient. This is a safety-tracking category.
Full definition in the glossary →- Device Difficult To Use 9,916 reports
Wrong Technique in Product Usage Process 9,479 reports
A report that the medication was used or administered with the wrong technique, such as an incorrect injection or inhaler method. This is a usage category, not a sign of a problem with the drug itself.
Full definition in the glossary →Drug Dose Omission by Device 6,585 reports
A report that a dose was missed because a device, such as a pump or injector, did not deliver it. This is a usage and device category.
Full definition in the glossary →Migraine 4,943 reports
A severe, often throbbing headache, sometimes with nausea or sensitivity to light and sound.
Full definition in the glossary → See all drugs reporting this event →Drug Ineffective 4,310 reports
A report that the medication did not work as expected for the person taking it. This is a reporting category, not a sign the drug is defective. It simply means someone felt it was not helping their condition.
Full definition in the glossary →Headache 3,342 reports
Pain in the head or upper neck.
Full definition in the glossary → See all drugs reporting this event →Constipation 3,179 reports
Difficulty passing stool, or having fewer bowel movements than usual.
Full definition in the glossary → See all drugs reporting this event →Product Storage Error 2,974 reports
A report that a medication was stored incorrectly, for example at the wrong temperature. This is a handling category, not a sign of a problem with the drug.
Full definition in the glossary →Injection Site Pain 2,848 reports
Pain at the spot on the body where a medication was injected.
Full definition in the glossary →Off Label Use 2,706 reports
Using a medication for a condition or in a way that the FDA has not officially approved. This is common and often legal, and a report of it does not mean something went wrong. Doctors sometimes prescribe drugs off label based on their judgment.
Full definition in the glossary →Nausea 2,374 reports
The feeling of sickness in your stomach that often comes before vomiting.
Full definition in the glossary → See all drugs reporting this event →Fatigue 2,232 reports
Extreme tiredness or lack of energy that does not improve with rest.
Full definition in the glossary → See all drugs reporting this event →Alopecia 2,180 reports
Therapeutic Product Effect Incomplete 1,937 reports
A report that the medication only partly worked. Similar to drug ineffective, it reflects that someone felt the treatment did not fully help.
Full definition in the glossary →
Ranked by frequency of reports, not severity. The most-reported event is not necessarily the most dangerous or the most common in patients taking this drug.
Who Is Reporting
Demographics of patients in FAERS reports that included this information. Not all reports include patient demographics.
By Sex
View reporter sex data as a table
| Sex | Reports |
|---|---|
| Female | 37,922 |
| Male | 6,192 |
| Unknown | 19 |
By Age Group
View age group data as a table
| Age group | Reports |
|---|---|
| 0-17 | 284 |
| 18-34 | 4,884 |
| 35-49 | 11,224 |
| 50-64 | 10,863 |
| 65-74 | 4,341 |
| 75+ | 1,583 |
This shows who filed reports, reflecting who takes this drug and who tends to report, not who is at greatest risk.
Reported Outcomes
Outcomes recorded in FAERS reports that included Aimovig. A single report may involve multiple reactions, each with a different outcome. These categories are defined by FDA reporting guidelines, not by PillSignal.
View outcome data as a table
| Outcome | Reports |
|---|---|
| Non-Serious | 42,682 |
| Other Serious | 9,184 |
| Hospitalization | 4,099 |
| Disability | 2,714 |
| Death | 2,646 |
| Life-Threatening | 2,334 |
Serious outcomes are far more likely to be reported than mild ones, so this overstates how often outcomes are serious. A recorded death does not mean the drug caused it.
Report Volume Over Time
Number of FAERS reports received per quarter for Aimovig. Changes in volume may reflect shifts in prescribing rates, media attention, or reporting behavior, not changes in the medication's safety profile.
View report trend as a table
| Year | Reports |
|---|---|
| 2009 | 1 |
| 2014 | 1 |
| 2015 | 5 |
| 2016 | 4 |
| 2017 | 10 |
| 2018 | 7,440 |
| 2019 | 11,258 |
| 2020 | 8,628 |
| 2021 | 6,012 |
| 2022 | 5,929 |
| 2023 | 5,749 |
| 2024 | 5,175 |
| 2025 | 3,082 |
| 2026 (partial) | 577 |
The steep increase around 2004 reflects the FDA's move to electronic submission, not a change in this drug's safety. Trends track reporting volume, not risk.
Medications commonly reported with Aimovig
In FDA adverse event reports that mention Aimovig, these medications appeared most often in the same report.
- Topiramate (3,685 reports)
- Topiramate Spinkle (2,752 reports)
- Diclofenac (2,620 reports)
- Acetaminophen (2,619 reports)
- Secukinumab (2,557 reports)
This reflects co-occurrence in submitted reports, not evidence of drug interaction or combined risk. People often report several medications taken for the same condition or for unrelated reasons. Talk to a doctor or pharmacist about your specific medications.
Related Drugs
Other medications with similar adverse event profiles in FDA FAERS reports.
Data Source
This data is sourced from the FDA's Adverse Event Monitoring System (AEMS), formerly FAERS, via the OpenFDA API. PillSignal is not affiliated with the FDA.
View this data on the FDA website →Data last updated: June 2026