These are medications for which migraine appears among the most-reported events in FDA adverse event reports. A report does not mean the drug caused the event. Report counts largely reflect how widely a drug is used and how often events are reported; they cannot be used to compare or rank drugs by risk. This list shows drugs where this event is among their top reported reactions, not every drug ever associated with it. This information is not medical advice. Do not stop or change a medication based on this data; discuss any concerns with your healthcare provider. Data from the FDA Adverse Event Monitoring System (AEMS), formerly FAERS, via OpenFDA.

A severe, often throbbing headache, sometimes with nausea or sensitivity to light and sound. Full definition in the glossary →

Medications with FDA adverse event reports of migraine, by report count
DrugReports of this event% of drug's total reports
Aimovig4,9439.2%
Topamax4,2924.8%
Naproxen3,0993.5%
Emgality2,9639.8%
Imitrex2,7427.4%
Naprosyn2,4523.2%
Mirena1,8981.4%
Tysabri1,8481.0%
Xyrem1,3582.2%
Gilenya1,1781.4%
Maxalt9129.9%
Estrace9111.7%
Vivelle-dot8301.8%
Adderall XR8242.0%
Climara8151.7%
Minivelle7991.7%
Vagifem7981.7%
NuvaRing7883.7%
Imvexxy7841.7%
Estrogen 4x7831.7%
Estradiol Transdermal System7821.6%
Estring7711.6%
Estrogel7691.7%
Divigel7451.7%
Evamist7431.7%
Yuvafem7381.7%
Dotti7371.7%
Elestrin7371.7%
Lyllana7371.7%
Menostar7361.7%
Estradiol7351.7%
Estradiol Vaginal7351.7%
Estradiol 15577341.7%
Estradiol Vaginal Inserts7341.7%
Estrogen Phenolic7341.7%
Adderall7292.1%
Strattera6352.7%
Provigil5981.9%
Excedrin Migraine5953.5%
Kesimpta5611.7%
Dapagliflozin5281.8%
Vyvanse4951.5%
Atacand4691.8%
Lupron Depot4661.6%
Zanaflex4242.4%
Nuvigil3641.7%
Desyrel3212.1%
Pristiq Extended-release3201.4%
Yasmin2941.2%
Depo-provera2781.2%
Retin-A2743.7%
Northera2061.0%
Nplate1551.1%
Prempro1420.6%
Pristiq491.5%

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