Trulicitydulaglutide
According to the FDA label: TRULICITY ® is indicated: As an adjunct to diet and exercise to improve glycemic control in adults and pediatric patients 10 years of age and older with type 2 diabetes mellitus. To reduce the risk of major adverse cardiovascular events (cardiovascular death, non-fatal myocardial infarction, or non-fatal stroke) in adults with type 2 diabetes mellitus who have established cardiovascular disease or multiple cardiovascular risk factors.
86,770 adverse event reports submitted to the FDA (2011–2026)
Top Reported Adverse Events
The most frequently reported events in association with Trulicity in the FAERS database. These are events reported by patients taking this medication, not necessarily caused by it. A single report may include multiple events.
Show these terms with plain-language definitions
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Nausea 10,199 reports
The feeling of sickness in your stomach that often comes before vomiting.
Full definition in the glossary → See all drugs reporting this event →Injection Site Pain 9,872 reports
Pain at the spot on the body where a medication was injected.
Full definition in the glossary →Blood Glucose Increased 9,831 reports
A blood test result showing a higher than normal blood sugar level.
Full definition in the glossary →Diarrhoea 5,948 reports
Loose or watery bowel movements, often frequent. Also spelled diarrhea in American English.
Full definition in the glossary → See all drugs reporting this event →Vomiting 5,608 reports
Throwing up the contents of the stomach.
Full definition in the glossary → See all drugs reporting this event →Incorrect Dose Administered 5,535 reports
A report that the wrong dose was given or taken. This is a usage category, not a sign of a problem with the drug itself.
Full definition in the glossary →Inappropriate Schedule of Product Administration 3,831 reports
A report that the medication was taken on the wrong schedule, such as too often, not often enough, or at the wrong time. This is a usage category, not a sign of a problem with the drug.
Full definition in the glossary →Drug Ineffective 3,602 reports
A report that the medication did not work as expected for the person taking it. This is a reporting category, not a sign the drug is defective. It simply means someone felt it was not helping their condition.
Full definition in the glossary →Weight Decreased 3,390 reports
Decreased Appetite 3,227 reports
Injection Site Haemorrhage 3,145 reports
Bleeding at the spot where a medication was injected. Also spelled hemorrhage in American English.
Full definition in the glossary →Extra Dose Administered 3,140 reports
A report that more doses of a medication were taken than directed. This is a usage category.
Full definition in the glossary →Glycosylated Haemoglobin Increased 2,932 reports
A higher than normal result on the HbA1c blood test, which reflects average blood sugar over the past few months. Also spelled hemoglobin in American English.
Full definition in the glossary →Fatigue 2,441 reports
Extreme tiredness or lack of energy that does not improve with rest.
Full definition in the glossary → See all drugs reporting this event →Abdominal Pain Upper 2,428 reports
Pain in the upper part of the belly, above the navel.
Full definition in the glossary →
Ranked by frequency of reports, not severity. The most-reported event is not necessarily the most dangerous or the most common in patients taking this drug.
Who Is Reporting
Demographics of patients in FAERS reports that included this information. Not all reports include patient demographics.
By Sex
View reporter sex data as a table
| Sex | Reports |
|---|---|
| Female | 45,048 |
| Male | 32,779 |
| Unknown | 11 |
By Age Group
View age group data as a table
| Age group | Reports |
|---|---|
| 0-17 | 134 |
| 18-34 | 833 |
| 35-49 | 5,074 |
| 50-64 | 15,596 |
| 65-74 | 11,388 |
| 75+ | 5,795 |
This shows who filed reports, reflecting who takes this drug and who tends to report, not who is at greatest risk.
Reported Outcomes
Outcomes recorded in FAERS reports that included Trulicity. A single report may involve multiple reactions, each with a different outcome. These categories are defined by FDA reporting guidelines, not by PillSignal.
View outcome data as a table
| Outcome | Reports |
|---|---|
| Non-Serious | 64,578 |
| Other Serious | 13,682 |
| Hospitalization | 10,332 |
| Death | 1,632 |
| Life-Threatening | 999 |
| Disability | 658 |
Serious outcomes are far more likely to be reported than mild ones, so this overstates how often outcomes are serious. A recorded death does not mean the drug caused it.
Report Volume Over Time
Number of FAERS reports received per quarter for Trulicity. Changes in volume may reflect shifts in prescribing rates, media attention, or reporting behavior, not changes in the medication's safety profile.
View report trend as a table
| Year | Reports |
|---|---|
| 2011 | 1 |
| 2012 | 4 |
| 2014 | 14 |
| 2015 | 1,678 |
| 2016 | 3,893 |
| 2017 | 6,225 |
| 2018 | 7,420 |
| 2019 | 9,334 |
| 2020 | 10,676 |
| 2021 | 12,619 |
| 2022 | 11,156 |
| 2023 | 9,511 |
| 2024 | 7,284 |
| 2025 | 5,858 |
| 2026 (partial) | 1,097 |
The steep increase around 2004 reflects the FDA's move to electronic submission, not a change in this drug's safety. Trends track reporting volume, not risk.
Medications commonly reported with Trulicity
In FDA adverse event reports that mention Trulicity, these medications appeared most often in the same report.
- Metformin (16,692 reports)
- Insulin Glargine (7,439 reports)
- Empagliflozin (4,098 reports)
- Insulin Lispro (3,651 reports)
- Glipizide (2,680 reports)
This reflects co-occurrence in submitted reports, not evidence of drug interaction or combined risk. People often report several medications taken for the same condition or for unrelated reasons. Talk to a doctor or pharmacist about your specific medications.
Related Drugs
Other medications with similar adverse event profiles in FDA FAERS reports.
Data Source
This data is sourced from the FDA's Adverse Event Monitoring System (AEMS), formerly FAERS, via the OpenFDA API. PillSignal is not affiliated with the FDA.
View this data on the FDA website →Data last updated: June 2026