Truvadaemtricitabine + tenofovir disoproxil
45,136 adverse event reports submitted to the FDA (2004–2026)
Top Reported Adverse Events
The most frequently reported events in association with Truvada in the FAERS database. These are events reported by patients taking this medication, not necessarily caused by it. A single report may include multiple events.
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- Bone Density Decreased 16,540 reports
Chronic Kidney Disease 10,325 reports
A long-term, gradual loss of kidney function over months or years.
Full definition in the glossary →- Osteonecrosis 9,133 reports
- Bone Loss 9,075 reports
Renal Failure 8,991 reports
A serious decline in kidney function, where the kidneys can no longer filter waste properly.
Full definition in the glossary →- Multiple Fractures 8,157 reports
- Tooth Loss 8,107 reports
Renal Injury 8,004 reports
Damage to the kidneys. Renal means related to the kidneys. Related to acute kidney injury and renal impairment.
Full definition in the glossary →Osteoporosis 7,264 reports
A condition where bones become weak and more likely to break. It often appears in reports as a condition being treated.
Full definition in the glossary →- Skeletal Injury 7,173 reports
Pain 6,583 reports
A general report of physical discomfort, used when no more specific location is given.
Full definition in the glossary →Emotional Distress 6,349 reports
A report of emotional suffering such as upset, worry, or anguish. If you are struggling, the 988 Suicide and Crisis Lifeline (call or text 988 in the US) is available 24 hours a day.
Full definition in the glossary →Anxiety 5,939 reports
A feeling of worry, nervousness, or unease.
Full definition in the glossary → See all drugs reporting this event →Anhedonia 5,605 reports
A reduced ability to feel pleasure or interest in activities once enjoyed.
Full definition in the glossary →- Osteopenia 3,920 reports
Ranked by frequency of reports, not severity. The most-reported event is not necessarily the most dangerous or the most common in patients taking this drug.
Who Is Reporting
Demographics of patients in FAERS reports that included this information. Not all reports include patient demographics.
By Sex
View reporter sex data as a table
| Sex | Reports |
|---|---|
| Male | 29,319 |
| Female | 12,187 |
| Unknown | 120 |
By Age Group
View age group data as a table
| Age group | Reports |
|---|---|
| 0-17 | 679 |
| 18-34 | 5,109 |
| 35-49 | 11,090 |
| 50-64 | 10,706 |
| 65-74 | 1,333 |
| 75+ | 159 |
This shows who filed reports, reflecting who takes this drug and who tends to report, not who is at greatest risk.
Reported Outcomes
Outcomes recorded in FAERS reports that included Truvada. A single report may involve multiple reactions, each with a different outcome. These categories are defined by FDA reporting guidelines, not by PillSignal.
View outcome data as a table
| Outcome | Reports |
|---|---|
| Other Serious | 33,112 |
| Hospitalization | 7,593 |
| Non-Serious | 7,059 |
| Death | 1,802 |
| Life-Threatening | 1,040 |
| Disability | 707 |
Serious outcomes are far more likely to be reported than mild ones, so this overstates how often outcomes are serious. A recorded death does not mean the drug caused it.
Report Volume Over Time
Number of FAERS reports received per quarter for Truvada. Changes in volume may reflect shifts in prescribing rates, media attention, or reporting behavior, not changes in the medication's safety profile.
View report trend as a table
| Year | Reports |
|---|---|
| 2004 | 1 |
| 2005 | 150 |
| 2006 | 395 |
| 2007 | 518 |
| 2008 | 907 |
| 2009 | 1,203 |
| 2010 | 1,080 |
| 2011 | 986 |
| 2012 | 1,139 |
| 2013 | 1,243 |
| 2014 | 1,476 |
| 2015 | 1,660 |
| 2016 | 1,419 |
| 2017 | 1,295 |
| 2018 | 1,665 |
| 2019 | 2,994 |
| 2020 | 14,656 |
| 2021 | 4,706 |
| 2022 | 2,977 |
| 2023 | 1,587 |
| 2024 | 1,567 |
| 2025 | 1,329 |
| 2026 (partial) | 183 |
The steep increase around 2004 reflects the FDA's move to electronic submission, not a change in this drug's safety. Trends track reporting volume, not risk.
Medications commonly reported with Truvada
In FDA adverse event reports that mention Truvada, these medications appeared most often in the same report.
- Tenofovir Disoproxil (12,836 reports)
- Ritonavir (7,849 reports)
- Bictegravir Emtricitabine And Tenofovir Alafenamide (6,909 reports)
- Emtricitabine And Tenofovir Alafenamide (6,537 reports)
- Elvitegravir Cobicistat Emtricitabine And Tenofovir Disoproxil (5,451 reports)
This reflects co-occurrence in submitted reports, not evidence of drug interaction or combined risk. People often report several medications taken for the same condition or for unrelated reasons. Talk to a doctor or pharmacist about your specific medications.
Related Drugs
Other medications with similar adverse event profiles in FDA FAERS reports.
Data Source
This data is sourced from the FDA's Adverse Event Monitoring System (AEMS), formerly FAERS, via the OpenFDA API. PillSignal is not affiliated with the FDA.
View this data on the FDA website →Data last updated: June 2026