Norvirritonavir
According to the FDA label: Ritonavir tablets are indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection. Ritonavir tablets are HIV protease inhibitors indicated in combination with other antiretroviral agents for the treatment of HIV-1 infection ( 1 )
28,967 adverse event reports submitted to the FDA (2003–2026)
Top Reported Adverse Events
The most frequently reported events in association with Norvir in the FAERS database. These are events reported by patients taking this medication, not necessarily caused by it. A single report may include multiple events.
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Drug Interaction 2,548 reports
A report that two or more medications may have affected each other when taken together.
Full definition in the glossary →Foetal Exposure During Pregnancy 2,375 reports
A report noting that a developing baby was exposed to a medication during pregnancy. This is a tracking category for monitoring, not a description of harm by itself. Also spelled fetal in American English.
Full definition in the glossary →Anxiety 1,622 reports
A feeling of worry, nervousness, or unease.
Full definition in the glossary → See all drugs reporting this event →Pain 1,573 reports
A general report of physical discomfort, used when no more specific location is given.
Full definition in the glossary →Emotional Distress 1,388 reports
A report of emotional suffering such as upset, worry, or anguish. If you are struggling, the 988 Suicide and Crisis Lifeline (call or text 988 in the US) is available 24 hours a day.
Full definition in the glossary →Anhedonia 1,235 reports
A reduced ability to feel pleasure or interest in activities once enjoyed.
Full definition in the glossary →Maternal Exposure During Pregnancy 1,228 reports
A report noting that a pregnant person was exposed to a medication. This is a tracking category for monitoring use during pregnancy, not a description of harm by itself.
Full definition in the glossary →Nausea 1,055 reports
The feeling of sickness in your stomach that often comes before vomiting.
Full definition in the glossary → See all drugs reporting this event →Diarrhoea 1,022 reports
Loose or watery bowel movements, often frequent. Also spelled diarrhea in American English.
Full definition in the glossary → See all drugs reporting this event →Exposure During Pregnancy 998 reports
A report noting that a person was exposed to a medication during pregnancy. This is a tracking category for monitoring, not a description of harm by itself.
Full definition in the glossary →Renal Failure 950 reports
A serious decline in kidney function, where the kidneys can no longer filter waste properly.
Full definition in the glossary →Fatigue 904 reports
Extreme tiredness or lack of energy that does not improve with rest.
Full definition in the glossary → See all drugs reporting this event →Acute Kidney Injury 901 reports
A sudden drop in how well the kidneys are working. It is often temporary and can have many causes.
Full definition in the glossary →Chronic Kidney Disease 897 reports
A long-term, gradual loss of kidney function over months or years.
Full definition in the glossary →Depression 868 reports
A persistent low mood, loss of interest, or feelings of sadness. If you are struggling, the 988 Suicide and Crisis Lifeline (call or text 988 in the US) is available 24 hours a day.
Full definition in the glossary → See all drugs reporting this event →
Ranked by frequency of reports, not severity. The most-reported event is not necessarily the most dangerous or the most common in patients taking this drug.
Who Is Reporting
Demographics of patients in FAERS reports that included this information. Not all reports include patient demographics.
By Sex
View reporter sex data as a table
| Sex | Reports |
|---|---|
| Male | 15,133 |
| Female | 8,977 |
| Unknown | 230 |
By Age Group
View age group data as a table
| Age group | Reports |
|---|---|
| 0-17 | 1,304 |
| 18-34 | 3,198 |
| 35-49 | 6,561 |
| 50-64 | 5,561 |
| 65-74 | 1,007 |
| 75+ | 340 |
This shows who filed reports, reflecting who takes this drug and who tends to report, not who is at greatest risk.
Reported Outcomes
Outcomes recorded in FAERS reports that included Norvir. A single report may involve multiple reactions, each with a different outcome. These categories are defined by FDA reporting guidelines, not by PillSignal.
View outcome data as a table
| Outcome | Reports |
|---|---|
| Other Serious | 18,664 |
| Hospitalization | 9,625 |
| Death | 2,621 |
| Non-Serious | 2,605 |
| Life-Threatening | 1,327 |
| Disability | 745 |
Serious outcomes are far more likely to be reported than mild ones, so this overstates how often outcomes are serious. A recorded death does not mean the drug caused it.
Report Volume Over Time
Number of FAERS reports received per quarter for Norvir. Changes in volume may reflect shifts in prescribing rates, media attention, or reporting behavior, not changes in the medication's safety profile.
View report trend as a table
| Year | Reports |
|---|---|
| 2003 | 2 |
| 2004 | 568 |
| 2005 | 619 |
| 2006 | 798 |
| 2007 | 910 |
| 2008 | 1,077 |
| 2009 | 1,369 |
| 2010 | 1,353 |
| 2011 | 1,246 |
| 2012 | 1,487 |
| 2013 | 1,465 |
| 2014 | 1,585 |
| 2015 | 2,154 |
| 2016 | 2,283 |
| 2017 | 1,802 |
| 2018 | 1,932 |
| 2019 | 1,715 |
| 2020 | 1,901 |
| 2021 | 1,434 |
| 2022 | 1,368 |
| 2023 | 914 |
| 2024 | 564 |
| 2025 | 384 |
| 2026 (partial) | 37 |
The steep increase around 2004 reflects the FDA's move to electronic submission, not a change in this drug's safety. Trends track reporting volume, not risk.
Medications commonly reported with Norvir
In FDA adverse event reports that mention Norvir, these medications appeared most often in the same report.
- Darunavir (11,929 reports)
- Atazanavir (9,698 reports)
- Emtricitabine And Tenofovir Disoproxil (7,849 reports)
- Lamivudine (5,601 reports)
- Raltegravir (5,118 reports)
This reflects co-occurrence in submitted reports, not evidence of drug interaction or combined risk. People often report several medications taken for the same condition or for unrelated reasons. Talk to a doctor or pharmacist about your specific medications.
Related Drugs
Other medications with similar adverse event profiles in FDA FAERS reports.
Data Source
This data is sourced from the FDA's Adverse Event Monitoring System (AEMS), formerly FAERS, via the OpenFDA API. PillSignal is not affiliated with the FDA.
View this data on the FDA website →Data last updated: June 2026