Yazdrospirenone + ethinyl estradiol

Name: Yaz (drospirenone + ethinyl estradiol) — FDA Adverse Event Reports
Creator: PillSignal
License: https://open.fda.gov/license/

31,192 adverse event reports submitted to the FDA (2004–2026)

This data reflects voluntary reports submitted to the FDA's Adverse Event Monitoring System (AEMS), formerly the FDA Adverse Event Reporting System (FAERS). A report does not mean the medication caused the event. Data may be incomplete or contain errors. Learn more about AEMS. New to this data? Read our guide on how to interpret FDA adverse event reports →

New to FDA adverse event data? Here's how to read these reports →

Top Reported Adverse Events

The most frequently reported events in association with Yaz in the FAERS database. These are events reported by patients taking this medication, not necessarily caused by it. A single report may include multiple events.

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Pain 10,329 reports
A general report of physical discomfort, used when no more specific location is given.
Full definition in the glossary →
Injury 8,763 reports
A general report of physical harm to the body, used when no more specific type is given.
Full definition in the glossary →
Pulmonary Embolism 6,443 reports
A blockage in one of the arteries of the lungs, usually caused by a blood clot. This is a serious condition that needs urgent medical care.
Full definition in the glossary →
Deep Vein Thrombosis 5,873 reports
A blood clot that forms in a deep vein, usually in the leg. It can be serious if the clot travels to the lungs.
Full definition in the glossary →
Anxiety 5,264 reports
A feeling of worry, nervousness, or unease.
Full definition in the glossary → See all drugs reporting this event →
Emotional Distress 5,094 reports
A report of emotional suffering such as upset, worry, or anguish. If you are struggling, the 988 Suicide and Crisis Lifeline (call or text 988 in the US) is available 24 hours a day.
Full definition in the glossary →
Cholecystitis Chronic 4,475 reports
Gallbladder Disorder 3,271 reports
Cholelithiasis 3,258 reports
General Physical Health Deterioration 2,531 reports
A report that the person's overall physical health declined.
Full definition in the glossary →
Abdominal Pain 2,115 reports
Pain in the belly or stomach area.
Full definition in the glossary → See all drugs reporting this event →
Nausea 2,013 reports
The feeling of sickness in your stomach that often comes before vomiting.
Full definition in the glossary → See all drugs reporting this event →
Anhedonia 1,786 reports
A reduced ability to feel pleasure or interest in activities once enjoyed.
Full definition in the glossary →
Dyspnoea 1,581 reports
Shortness of breath or difficulty breathing. Also spelled dyspnea in American English.
Full definition in the glossary → See all drugs reporting this event →
Thrombosis 1,564 reports
The formation of a blood clot inside a blood vessel.
Full definition in the glossary →

Browse the full glossary →

Ranked by frequency of reports, not severity. The most-reported event is not necessarily the most dangerous or the most common in patients taking this drug.

Who Is Reporting

Demographics of patients in FAERS reports that included this information. Not all reports include patient demographics.

By Sex

View reporter sex data as a table

Yaz adverse event reports by reporter sex
Sex	Reports
Female	30,940
Male	44
Unknown	6

By Age Group

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Yaz adverse event reports by reporter age group
Age group	Reports
0-17	1,431
18-34	13,468
35-49	6,245
50-64	461
65-74	1

This shows who filed reports, reflecting who takes this drug and who tends to report, not who is at greatest risk.

Reported Outcomes

Outcomes recorded in FAERS reports that included Yaz. A single report may involve multiple reactions, each with a different outcome. These categories are defined by FDA reporting guidelines, not by PillSignal.

View outcome data as a table

Yaz adverse event reports by reported outcome
Outcome	Reports
Other Serious	14,983
Hospitalization	14,338
Non-Serious	7,055
Life-Threatening	1,246
Disability	791
Death	374

Serious outcomes are far more likely to be reported than mild ones, so this overstates how often outcomes are serious. A recorded death does not mean the drug caused it.

Report Volume Over Time

Number of FAERS reports received per quarter for Yaz. Changes in volume may reflect shifts in prescribing rates, media attention, or reporting behavior, not changes in the medication's safety profile.

View report trend as a table

Yaz adverse event reports by year
Year	Reports
2004	1
2006	19
2007	213
2008	2,509
2009	2,361
2010	1,750
2011	8,669
2012	7,360
2013	3,487
2014	1,798
2015	588
2016	450
2017	278
2018	271
2019	248
2020	239
2021	189
2022	202
2023	203
2024	145
2025	173
2026 (partial)	39

The steep increase around 2004 reflects the FDA's move to electronic submission, not a change in this drug's safety. Trends track reporting volume, not risk.

Medications commonly reported with Yaz

In FDA adverse event reports that mention Yaz, these medications appeared most often in the same report.

Ibuprofen (3,518 reports)
Ibupfrofen (2,348 reports)
Omeprazole (1,238 reports)
Albuterol (1,215 reports)
Levothyroxine (1,136 reports)

This reflects co-occurrence in submitted reports, not evidence of drug interaction or combined risk. People often report several medications taken for the same condition or for unrelated reasons. Talk to a doctor or pharmacist about your specific medications.

Other medications with similar adverse event profiles in FDA FAERS reports.

Data Source

This data is sourced from the FDA's Adverse Event Monitoring System (AEMS), formerly FAERS, via the OpenFDA API. PillSignal is not affiliated with the FDA.

View this data on the FDA website →

Data last updated: June 2026