Allegrafexofenadine
According to the FDA label: Uses temporarily relieves these symptoms due to hay fever or other upper respiratory allergies: runny nose itchy, watery eyes sneezing itching of the nose or throat
20,489 adverse event reports submitted to the FDA (2004–2026)
Top Reported Adverse Events
The most frequently reported events in association with Allegra in the FAERS database. These are events reported by patients taking this medication, not necessarily caused by it. A single report may include multiple events.
Show these terms with plain-language definitions
Tap any term below for a plain-language definition.
Drug Ineffective 3,636 reports
A report that the medication did not work as expected for the person taking it. This is a reporting category, not a sign the drug is defective. It simply means someone felt it was not helping their condition.
Full definition in the glossary →Headache 910 reports
Pain in the head or upper neck.
Full definition in the glossary → See all drugs reporting this event →Fatigue 886 reports
Extreme tiredness or lack of energy that does not improve with rest.
Full definition in the glossary → See all drugs reporting this event →Pruritus 812 reports
Nausea 806 reports
The feeling of sickness in your stomach that often comes before vomiting.
Full definition in the glossary → See all drugs reporting this event →No Adverse Event 739 reports
A report that was filed but did not actually describe any adverse event. This is a record-keeping category.
Full definition in the glossary →Diarrhoea 715 reports
Loose or watery bowel movements, often frequent. Also spelled diarrhea in American English.
Full definition in the glossary → See all drugs reporting this event →Extra Dose Administered 709 reports
A report that more doses of a medication were taken than directed. This is a usage category.
Full definition in the glossary →Dizziness 672 reports
A feeling of being lightheaded, unsteady, or like the room is spinning.
Full definition in the glossary → See all drugs reporting this event →Rash 637 reports
An area of irritated, red, or bumpy skin.
Full definition in the glossary → See all drugs reporting this event →Dyspnoea 615 reports
Shortness of breath or difficulty breathing. Also spelled dyspnea in American English.
Full definition in the glossary → See all drugs reporting this event →Somnolence 607 reports
Drowsiness or strong sleepiness.
Full definition in the glossary → See all drugs reporting this event →Cough 579 reports
A reflex that clears the throat or airways.
Full definition in the glossary → See all drugs reporting this event →Insomnia 536 reports
Difficulty falling asleep or staying asleep.
Full definition in the glossary → See all drugs reporting this event →Pain 511 reports
A general report of physical discomfort, used when no more specific location is given.
Full definition in the glossary →
Ranked by frequency of reports, not severity. The most-reported event is not necessarily the most dangerous or the most common in patients taking this drug.
Who Is Reporting
Demographics of patients in FAERS reports that included this information. Not all reports include patient demographics.
By Sex
View reporter sex data as a table
| Sex | Reports |
|---|---|
| Female | 11,165 |
| Male | 5,062 |
| Unknown | 10 |
By Age Group
View age group data as a table
| Age group | Reports |
|---|---|
| 0-17 | 547 |
| 18-34 | 1,152 |
| 35-49 | 1,542 |
| 50-64 | 2,420 |
| 65-74 | 1,982 |
| 75+ | 1,921 |
This shows who filed reports, reflecting who takes this drug and who tends to report, not who is at greatest risk.
Reported Outcomes
Outcomes recorded in FAERS reports that included Allegra. A single report may involve multiple reactions, each with a different outcome. These categories are defined by FDA reporting guidelines, not by PillSignal.
View outcome data as a table
| Outcome | Reports |
|---|---|
| Non-Serious | 13,658 |
| Other Serious | 5,000 |
| Hospitalization | 2,788 |
| Death | 567 |
| Life-Threatening | 344 |
| Disability | 337 |
Serious outcomes are far more likely to be reported than mild ones, so this overstates how often outcomes are serious. A recorded death does not mean the drug caused it.
Report Volume Over Time
Number of FAERS reports received per quarter for Allegra. Changes in volume may reflect shifts in prescribing rates, media attention, or reporting behavior, not changes in the medication's safety profile.
View report trend as a table
| Year | Reports |
|---|---|
| 2004 | 148 |
| 2005 | 141 |
| 2006 | 29 |
| 2007 | 31 |
| 2008 | 37 |
| 2009 | 49 |
| 2010 | 21 |
| 2011 | 40 |
| 2012 | 124 |
| 2013 | 168 |
| 2014 | 175 |
| 2015 | 386 |
| 2016 | 2,029 |
| 2017 | 2,223 |
| 2018 | 2,736 |
| 2019 | 1,265 |
| 2020 | 1,286 |
| 2021 | 1,291 |
| 2022 | 1,534 |
| 2023 | 2,106 |
| 2024 | 2,006 |
| 2025 | 2,086 |
| 2026 (partial) | 578 |
The steep increase around 2004 reflects the FDA's move to electronic submission, not a change in this drug's safety. Trends track reporting volume, not risk.
Medications commonly reported with Allegra
In FDA adverse event reports that mention Allegra, these medications appeared most often in the same report.
- Ergocalciferol (2,493 reports)
- Fluticasone (2,139 reports)
- Dupilumab (2,083 reports)
- Albuterol (1,996 reports)
- Montelukast (1,923 reports)
This reflects co-occurrence in submitted reports, not evidence of drug interaction or combined risk. People often report several medications taken for the same condition or for unrelated reasons. Talk to a doctor or pharmacist about your specific medications.
Related Drugs
Other medications with similar adverse event profiles in FDA FAERS reports.
Data Source
This data is sourced from the FDA's Adverse Event Monitoring System (AEMS), formerly FAERS, via the OpenFDA API. PillSignal is not affiliated with the FDA.
View this data on the FDA website →Data last updated: June 2026