Wegovysemaglutide
According to the FDA label: WEGOVY injection is indicated in combination with a reduced calorie diet and increased physical activity: • to reduce the risk of major adverse cardiovascular (CV) events (CV death, non-fatal myocardial infarction, or non-fatal stroke) in adults with established CV disease and either obesity or overweight. • to reduce excess body weight and maintain weight reduction long term in: o adults and pediatric patients aged 12 years and older with obesity.
19,958 adverse event reports submitted to the FDA (2014–2026)
Top Reported Adverse Events
The most frequently reported events in association with Wegovy in the FAERS database. These are events reported by patients taking this medication, not necessarily caused by it. A single report may include multiple events.
Show these terms with plain-language definitions
Tap any term below for a plain-language definition.
Nausea 2,654 reports
The feeling of sickness in your stomach that often comes before vomiting.
Full definition in the glossary → See all drugs reporting this event →Vomiting 1,898 reports
Throwing up the contents of the stomach.
Full definition in the glossary → See all drugs reporting this event →Diarrhoea 1,279 reports
Loose or watery bowel movements, often frequent. Also spelled diarrhea in American English.
Full definition in the glossary → See all drugs reporting this event →Off Label Use 1,157 reports
Using a medication for a condition or in a way that the FDA has not officially approved. This is common and often legal, and a report of it does not mean something went wrong. Doctors sometimes prescribe drugs off label based on their judgment.
Full definition in the glossary →Fatigue 1,004 reports
Extreme tiredness or lack of energy that does not improve with rest.
Full definition in the glossary → See all drugs reporting this event →Constipation 859 reports
Difficulty passing stool, or having fewer bowel movements than usual.
Full definition in the glossary → See all drugs reporting this event →Headache 783 reports
Pain in the head or upper neck.
Full definition in the glossary → See all drugs reporting this event →Dizziness 745 reports
A feeling of being lightheaded, unsteady, or like the room is spinning.
Full definition in the glossary → See all drugs reporting this event →Weight Increased 742 reports
Drug Ineffective 682 reports
A report that the medication did not work as expected for the person taking it. This is a reporting category, not a sign the drug is defective. It simply means someone felt it was not helping their condition.
Full definition in the glossary →Decreased Appetite 645 reports
Inappropriate Schedule of Product Administration 627 reports
A report that the medication was taken on the wrong schedule, such as too often, not often enough, or at the wrong time. This is a usage category, not a sign of a problem with the drug.
Full definition in the glossary →Abdominal Pain 589 reports
Pain in the belly or stomach area.
Full definition in the glossary → See all drugs reporting this event →Weight Decreased 583 reports
Abdominal Pain Upper 554 reports
Pain in the upper part of the belly, above the navel.
Full definition in the glossary →
Ranked by frequency of reports, not severity. The most-reported event is not necessarily the most dangerous or the most common in patients taking this drug.
Who Is Reporting
Demographics of patients in FAERS reports that included this information. Not all reports include patient demographics.
By Sex
View reporter sex data as a table
| Sex | Reports |
|---|---|
| Female | 13,087 |
| Male | 4,667 |
| Unknown | 23 |
By Age Group
View age group data as a table
| Age group | Reports |
|---|---|
| 0-17 | 160 |
| 18-34 | 1,348 |
| 35-49 | 3,085 |
| 50-64 | 4,435 |
| 65-74 | 1,910 |
| 75+ | 783 |
This shows who filed reports, reflecting who takes this drug and who tends to report, not who is at greatest risk.
Reported Outcomes
Outcomes recorded in FAERS reports that included Wegovy. A single report may involve multiple reactions, each with a different outcome. These categories are defined by FDA reporting guidelines, not by PillSignal.
View outcome data as a table
| Outcome | Reports |
|---|---|
| Other Serious | 9,254 |
| Non-Serious | 7,865 |
| Hospitalization | 4,493 |
| Life-Threatening | 692 |
| Disability | 556 |
| Death | 314 |
Serious outcomes are far more likely to be reported than mild ones, so this overstates how often outcomes are serious. A recorded death does not mean the drug caused it.
Report Volume Over Time
Number of FAERS reports received per quarter for Wegovy. Changes in volume may reflect shifts in prescribing rates, media attention, or reporting behavior, not changes in the medication's safety profile.
View report trend as a table
| Year | Reports |
|---|---|
| 2014 | 1 |
| 2015 | 1 |
| 2016 | 7 |
| 2017 | 5 |
| 2018 | 19 |
| 2019 | 173 |
| 2020 | 188 |
| 2021 | 915 |
| 2022 | 1,797 |
| 2023 | 2,404 |
| 2024 | 4,920 |
| 2025 | 7,610 |
| 2026 (partial) | 1,918 |
The steep increase around 2004 reflects the FDA's move to electronic submission, not a change in this drug's safety. Trends track reporting volume, not risk.
Medications commonly reported with Wegovy
In FDA adverse event reports that mention Wegovy, these medications appeared most often in the same report.
- Metformin (1,917 reports)
- Acetaminophen (838 reports)
- Aspirin (833 reports)
- Ergocalciferol (762 reports)
- Rosuvastatin (710 reports)
This reflects co-occurrence in submitted reports, not evidence of drug interaction or combined risk. People often report several medications taken for the same condition or for unrelated reasons. Talk to a doctor or pharmacist about your specific medications.
Related Drugs
Other medications with similar adverse event profiles in FDA FAERS reports.
Data Source
This data is sourced from the FDA's Adverse Event Monitoring System (AEMS), formerly FAERS, via the OpenFDA API. PillSignal is not affiliated with the FDA.
View this data on the FDA website →Data last updated: June 2026