Zyprexa Relprevvolanzapine
According to the FDA label: Olanzapine is an atypical antipsychotic indicated: As oral formulation for the: Treatment of schizophrenia. ( 1.1 ) Adults: Efficacy was established in three clinical trials in patients with schizophrenia: two 6-week trials and one maintenance trial. ( 14.1 ) Adolescents (ages 13-17): Efficacy was established in one 6-week trial in patients with schizophrenia ( 14.1 ).
40,583 adverse event reports submitted to the FDA (2003–2026)
Top Reported Adverse Events
The most frequently reported events in association with Zyprexa Relprevv in the FAERS database. These are events reported by patients taking this medication, not necessarily caused by it. A single report may include multiple events.
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Diabetes Mellitus 4,875 reports
A condition where the body cannot properly regulate blood sugar, commonly called diabetes.
Full definition in the glossary →Weight Increased 4,136 reports
Drug Ineffective 1,934 reports
A report that the medication did not work as expected for the person taking it. This is a reporting category, not a sign the drug is defective. It simply means someone felt it was not helping their condition.
Full definition in the glossary →Off Label Use 1,880 reports
Using a medication for a condition or in a way that the FDA has not officially approved. This is common and often legal, and a report of it does not mean something went wrong. Doctors sometimes prescribe drugs off label based on their judgment.
Full definition in the glossary →Pancreatitis 1,735 reports
Inflammation of the pancreas, which can cause severe belly pain.
Full definition in the glossary →Hypertension 1,683 reports
Type 2 Diabetes Mellitus 1,631 reports
The most common form of diabetes, where the body does not use insulin properly. It often appears in reports as a condition being treated.
Full definition in the glossary →Anxiety 1,568 reports
A feeling of worry, nervousness, or unease.
Full definition in the glossary → See all drugs reporting this event →Nausea 1,437 reports
The feeling of sickness in your stomach that often comes before vomiting.
Full definition in the glossary → See all drugs reporting this event →Somnolence 1,403 reports
Drowsiness or strong sleepiness.
Full definition in the glossary → See all drugs reporting this event →Fatigue 1,375 reports
Extreme tiredness or lack of energy that does not improve with rest.
Full definition in the glossary → See all drugs reporting this event →Insomnia 1,345 reports
Difficulty falling asleep or staying asleep.
Full definition in the glossary → See all drugs reporting this event →Overdose 1,331 reports
Taking more of a medication than intended or recommended. This can be accidental.
Full definition in the glossary →Depression 1,283 reports
A persistent low mood, loss of interest, or feelings of sadness. If you are struggling, the 988 Suicide and Crisis Lifeline (call or text 988 in the US) is available 24 hours a day.
Full definition in the glossary → See all drugs reporting this event →Suicide Attempt 1,273 reports
A report that a person attempted suicide. Its presence in reports does not establish that a medication was the cause. If you or someone you know is struggling, the 988 Suicide and Crisis Lifeline (call or text 988 in the US) is available 24 hours a day.
Full definition in the glossary →
Ranked by frequency of reports, not severity. The most-reported event is not necessarily the most dangerous or the most common in patients taking this drug.
Who Is Reporting
Demographics of patients in FAERS reports that included this information. Not all reports include patient demographics.
By Sex
View reporter sex data as a table
| Sex | Reports |
|---|---|
| Female | 19,624 |
| Male | 18,597 |
| Unknown | 228 |
By Age Group
View age group data as a table
| Age group | Reports |
|---|---|
| 0-17 | 1,307 |
| 18-34 | 5,714 |
| 35-49 | 7,178 |
| 50-64 | 5,925 |
| 65-74 | 2,489 |
| 75+ | 1,995 |
This shows who filed reports, reflecting who takes this drug and who tends to report, not who is at greatest risk.
Reported Outcomes
Outcomes recorded in FAERS reports that included Zyprexa Relprevv. A single report may involve multiple reactions, each with a different outcome. These categories are defined by FDA reporting guidelines, not by PillSignal.
View outcome data as a table
| Outcome | Reports |
|---|---|
| Other Serious | 18,456 |
| Hospitalization | 15,574 |
| Non-Serious | 9,199 |
| Death | 4,490 |
| Life-Threatening | 2,214 |
| Disability | 1,463 |
Serious outcomes are far more likely to be reported than mild ones, so this overstates how often outcomes are serious. A recorded death does not mean the drug caused it.
Report Volume Over Time
Number of FAERS reports received per quarter for Zyprexa Relprevv. Changes in volume may reflect shifts in prescribing rates, media attention, or reporting behavior, not changes in the medication's safety profile.
View report trend as a table
| Year | Reports |
|---|---|
| 2003 | 1 |
| 2004 | 1,651 |
| 2005 | 2,497 |
| 2006 | 3,075 |
| 2007 | 2,995 |
| 2008 | 1,331 |
| 2009 | 2,936 |
| 2010 | 2,551 |
| 2011 | 2,498 |
| 2012 | 1,840 |
| 2013 | 1,224 |
| 2014 | 1,275 |
| 2015 | 5,915 |
| 2016 | 1,368 |
| 2017 | 1,532 |
| 2018 | 1,380 |
| 2019 | 1,372 |
| 2020 | 1,176 |
| 2021 | 936 |
| 2022 | 960 |
| 2023 | 790 |
| 2024 | 579 |
| 2025 | 574 |
| 2026 (partial) | 127 |
The steep increase around 2004 reflects the FDA's move to electronic submission, not a change in this drug's safety. Trends track reporting volume, not risk.
Medications commonly reported with Zyprexa Relprevv
In FDA adverse event reports that mention Zyprexa Relprevv, these medications appeared most often in the same report.
- Quetiapine (6,352 reports)
- Risperidone (5,107 reports)
- Aripiprazole (4,217 reports)
- Lorazepam (2,990 reports)
- Divalproex (2,932 reports)
This reflects co-occurrence in submitted reports, not evidence of drug interaction or combined risk. People often report several medications taken for the same condition or for unrelated reasons. Talk to a doctor or pharmacist about your specific medications.
Related Drugs
Other medications with similar adverse event profiles in FDA FAERS reports.
Data Source
This data is sourced from the FDA's Adverse Event Monitoring System (AEMS), formerly FAERS, via the OpenFDA API. PillSignal is not affiliated with the FDA.
View this data on the FDA website →Data last updated: June 2026