Geodonziprasidone
According to the FDA label: Ziprasidone capsules are indicated for the treatment of schizophrenia, as monotherapy for the acute treatment of bipolar manic or mixed episodes, and as an adjunct to lithium or valproate for the maintenance treatment of bipolar disorder.
18,703 adverse event reports submitted to the FDA (2004–2026)
Top Reported Adverse Events
The most frequently reported events in association with Geodon in the FAERS database. These are events reported by patients taking this medication, not necessarily caused by it. A single report may include multiple events.
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Drug Ineffective 1,802 reports
A report that the medication did not work as expected for the person taking it. This is a reporting category, not a sign the drug is defective. It simply means someone felt it was not helping their condition.
Full definition in the glossary →Weight Increased 1,329 reports
Diabetes Mellitus 1,083 reports
A condition where the body cannot properly regulate blood sugar, commonly called diabetes.
Full definition in the glossary →Anxiety 935 reports
A feeling of worry, nervousness, or unease.
Full definition in the glossary → See all drugs reporting this event →Type 2 Diabetes Mellitus 866 reports
The most common form of diabetes, where the body does not use insulin properly. It often appears in reports as a condition being treated.
Full definition in the glossary →Insomnia 857 reports
Difficulty falling asleep or staying asleep.
Full definition in the glossary → See all drugs reporting this event →Depression 845 reports
A persistent low mood, loss of interest, or feelings of sadness. If you are struggling, the 988 Suicide and Crisis Lifeline (call or text 988 in the US) is available 24 hours a day.
Full definition in the glossary → See all drugs reporting this event →Suicide Attempt 840 reports
A report that a person attempted suicide. Its presence in reports does not establish that a medication was the cause. If you or someone you know is struggling, the 988 Suicide and Crisis Lifeline (call or text 988 in the US) is available 24 hours a day.
Full definition in the glossary →Dyskinesia 837 reports
Involuntary, uncontrolled movements of the body.
Full definition in the glossary →Dystonia 791 reports
Involuntary muscle contractions that cause twisting movements or abnormal postures.
Full definition in the glossary →Somnolence 781 reports
Drowsiness or strong sleepiness.
Full definition in the glossary → See all drugs reporting this event →Fatigue 757 reports
Extreme tiredness or lack of energy that does not improve with rest.
Full definition in the glossary → See all drugs reporting this event →Sedation 753 reports
A state of calm, drowsiness, or reduced alertness.
Full definition in the glossary →Nausea 724 reports
The feeling of sickness in your stomach that often comes before vomiting.
Full definition in the glossary → See all drugs reporting this event →Tremor 723 reports
Involuntary shaking or trembling, often in the hands.
Full definition in the glossary → See all drugs reporting this event →
Ranked by frequency of reports, not severity. The most-reported event is not necessarily the most dangerous or the most common in patients taking this drug.
Who Is Reporting
Demographics of patients in FAERS reports that included this information. Not all reports include patient demographics.
By Sex
View reporter sex data as a table
| Sex | Reports |
|---|---|
| Female | 10,298 |
| Male | 6,264 |
| Unknown | 199 |
By Age Group
View age group data as a table
| Age group | Reports |
|---|---|
| 0-17 | 841 |
| 18-34 | 2,838 |
| 35-49 | 3,086 |
| 50-64 | 2,280 |
| 65-74 | 601 |
| 75+ | 242 |
This shows who filed reports, reflecting who takes this drug and who tends to report, not who is at greatest risk.
Reported Outcomes
Outcomes recorded in FAERS reports that included Geodon. A single report may involve multiple reactions, each with a different outcome. These categories are defined by FDA reporting guidelines, not by PillSignal.
View outcome data as a table
| Outcome | Reports |
|---|---|
| Other Serious | 9,912 |
| Non-Serious | 5,608 |
| Hospitalization | 4,591 |
| Death | 1,312 |
| Life-Threatening | 667 |
| Disability | 520 |
Serious outcomes are far more likely to be reported than mild ones, so this overstates how often outcomes are serious. A recorded death does not mean the drug caused it.
Report Volume Over Time
Number of FAERS reports received per quarter for Geodon. Changes in volume may reflect shifts in prescribing rates, media attention, or reporting behavior, not changes in the medication's safety profile.
View report trend as a table
| Year | Reports |
|---|---|
| 2004 | 563 |
| 2005 | 675 |
| 2006 | 722 |
| 2007 | 860 |
| 2008 | 460 |
| 2009 | 1,112 |
| 2010 | 2,777 |
| 2011 | 1,729 |
| 2012 | 1,175 |
| 2013 | 747 |
| 2014 | 631 |
| 2015 | 849 |
| 2016 | 888 |
| 2017 | 750 |
| 2018 | 696 |
| 2019 | 780 |
| 2020 | 738 |
| 2021 | 652 |
| 2022 | 627 |
| 2023 | 472 |
| 2024 | 353 |
| 2025 | 349 |
| 2026 (partial) | 98 |
The steep increase around 2004 reflects the FDA's move to electronic submission, not a change in this drug's safety. Trends track reporting volume, not risk.
Medications commonly reported with Geodon
In FDA adverse event reports that mention Geodon, these medications appeared most often in the same report.
- Quetiapine (4,006 reports)
- Olanzapine (2,874 reports)
- Risperidone (2,712 reports)
- Aripiprazole (2,706 reports)
- Clonazepam (2,192 reports)
This reflects co-occurrence in submitted reports, not evidence of drug interaction or combined risk. People often report several medications taken for the same condition or for unrelated reasons. Talk to a doctor or pharmacist about your specific medications.
Related Drugs
Other medications with similar adverse event profiles in FDA FAERS reports.
Data Source
This data is sourced from the FDA's Adverse Event Monitoring System (AEMS), formerly FAERS, via the OpenFDA API. PillSignal is not affiliated with the FDA.
View this data on the FDA website →Data last updated: June 2026